How to Freeze and Thaw Brain Tissue

Stories about humans waking up from cryosleep have dominated popular culture for decades in the Alien films, Cameron’s Avatar, and Nolan’s Interstellar. While these films are out there, space- and time-wise, we know the science exists offscreen. Globally, there are about 500 people in cryogenic preservation: 300 of them in the United States. Thousands more … Read more

How to Freeze and Thaw Brain Tissue

Stories about humans waking up from cryosleep have dominated popular culture for decades in the Alien films, Cameron’s Avatar, and Nolan’s Interstellar. While these films are out there, space- and time-wise, we know the science exists offscreen. Globally, there are about 500 people in cryogenic preservation: 300 of them in the United States. Thousands more … Read more

AI in Ulcerative Colitis: Enhancing Clinical Workflow

Ryan W. Stidham, MD, MS Artificial intelligence (AI) is used in ulcerative colitis to assist in the assessment, monitoring, and management of disease. To explain how this technology is being applied in the clinical setting, Janelle McSwiggin, MSN, RN, spoke with Ryan W. Stidham, MD, MS, associate professor in the Division of Gastroenterology at University … Read more

Computer-Aided Colonoscopy Not Ready for Prime Time

An American Gastroenterological Association (AGA) multidisciplinary panel has reached the conclusion that no recommendation can be made for or against the use of computer-aided detection (CADe)–assisted colonoscopy for colorectal cancer (CRC), the third most common cause of cancer mortality in the United States. The systematic data review is a collaboration between the AGA and The … Read more

Carbohydrate Intolerance Common in Gut-Brain Disorders

TOPLINE: A substantial proportion of patients with disorders of gut-brain interaction had carbohydrate intolerance. These patients experienced more severe irritable bowel syndrome (IBS) and somatic symptoms, along with a lower quality of life, than those without carbohydrate intolerance. METHODOLOGY: Patients with disorders of gut-brain interaction may have symptoms of carbohydrate maldigestion or malabsorption; however, routine … Read more

Blood Test Predicts Melanoma Recurrence

TOPLINE: Droplet digital polymerase chain reaction (PCR) measurements of circulating tumor DNA (ctDNA) identify patients with stage III melanoma who are at high risk for early recurrence during adjuvant targeted therapy. The blood-based biomarker outperforms traditional prognostic indicators including tumor mutational burden and interferon gamma gene expression. METHODOLOGY: Cell-free ctDNA is an established measure of … Read more

Pediatric Cardiology: Highlights From Cardiology 2025

Cardiology 2025, the 28th Annual Update on Pediatric and Congenital Cardiovascular Disease, took place from February 19 to 23 in Lake Buena Vista, Florida. The conference, hosted by the Children’s Hospital of Philadelphia, brought together a diverse community of pediatric and congenital cardiovascular professionals and advocates, all united by this year’s theme: Hope, Heal, and … Read more

Risk Patterns Guide Surveillance Colonoscopy Decisions

TOPLINE: A new study revealed that patients with high-risk findings at both baseline and first surveillance colonoscopy (SC1) had a significantly higher risk for colorectal cancer (CRC) than the general population, requiring a second surveillance visit. Conversely, those with low-risk findings at SC1 did not require a second surveillance visit, regardless of their baseline findings. … Read more

Miracle Cure or Dangerous Trend?

A new social media trend is making headlines: Methylene blue is being touted as a cognitive booster and antiaging miracle. Influencers such as Ben Greenfield are promoting the use of this chemical to enhance brain performance, strengthen the immune system, and even prevent cancer without providing scientific evidence. Researchers have warned that methylene blue can … Read more

Modest Effects of Valacyclovir in Herpes Zoster Eye Disease

TOPLINE: Low-dose suppressive valacyclovir treatment of herpes zoster ophthalmicus (HZO) did not show significant benefits at 12 months but showed treatment superiority at 18 months and a reduction in the number of multiple episodes of keratitis or iritis at 12 and 18 months. METHODOLOGY: Researchers conducted a placebo-controlled randomized clinical trial across 95 sites in … Read more