TOPLINE: Zimlovisertib plus tofacitinib showed greater efficacy than tofacitinib alone in reducing Disease Activity Score in 28 joints using C-reactive protein (DAS28-CRP) in patients with rheumatoid arthritis (RA), with a significant reduction observed at week 12. METHODOLOGY: This randomized, phase 2 study, conducted across 77 centers in 10 countries, aimed to evaluate the efficacy, safety, … Read more
Ryan W. Stidham, MD, MS Artificial intelligence (AI) is used in ulcerative colitis to assist in the assessment, monitoring, and management of disease. To explain how this technology is being applied in the clinical setting, Janelle McSwiggin, MSN, RN, spoke with Ryan W. Stidham, MD, MS, associate professor in the Division of Gastroenterology at University … Read more
TOPLINE: Nearly 19 million US children live with at least one parent meeting Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition; DSM-5) criteria for substance use disorder (SUD), representing one quarter of all US children in 2023. Over 6.1 million of these children have parents with comorbid SUD and mental illness, making them particularly … Read more
TOPLINE: A substantial proportion of perimenopausal and menopausal women expressed willingness to undergo assessment for osteoporosis, especially among those of Chinese ethnicity and those with an older age, fracture history, and higher scores in perception of their osteoporosis risk. METHODOLOGY: Researchers conducted this cross-sectional study utilizing self-administered questionnaires to determine the factors that affect the … Read more
TOPLINE: Only 5% of patients with trauma experienced significant hypoxemia within the first 8 hours of care, with no difference observed between restrictive and liberal oxygen strategies. METHODOLOGY: This substudy of the randomized TRAUMOX2 trial included 60 adults with trauma injury (median age, 49 years; 75% men) who were randomly assigned to receive either a … Read more
TOPLINE: Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected monocytes, fibrocytes, and lymphocytes, leading to changes in gene expression and protein levels that may contribute to disease progression. METHODOLOGY: Researchers examined CLL cell–derived exosomes and their effects on healthy … Read more
TOPLINE: A recent study identified three clinically distinct vitiligo profiles on the basis of Vitiligo Patient Priority Outcomes (ViPPO) responses from real-world patient data. Classes with more severe emotional and social functioning impacts had more severe disease per physician assessment, visible areas of lesion involvement, and work productivity and quality-of-life (QoL) impairment. METHODOLOGY: Researchers collected … Read more
Archyde Allergies Linked to Higher Migraine Risk: New Research Sounds the Alarm Millions of Americans suffering from allergies may also be at increased risk for migraines, according to a recent meta-analysis published in the International Archives of Allergy and Immunology. Experts are urging doctors to consider this connection when treating patients. Published April 4, 2024 … Read more
TOPLINE: Allergic diseases such as atopic dermatitis, asthma, allergic rhinitis, and allergic conjunctivitis are associated with a significantly increased risk for migraine, according to a systematic review and meta-analysis. METHODOLOGY: Researchers searched databases to identify observational studies that examined the association between allergic diseases and migraine. They focused on 10 cohort and case-control studies with … Read more
An American Gastroenterological Association (AGA) multidisciplinary panel has reached the conclusion that no recommendation can be made for or against the use of computer-aided detection (CADe)–assisted colonoscopy for colorectal cancer (CRC), the third most common cause of cancer mortality in the United States. The systematic data review is a collaboration between the AGA and The … Read more