Rethinking Antibiotic Duration for Childhood UTIs: A New Approach to Treatment Table of Contents Rethinking Antibiotic Duration for Childhood UTIs: A New Approach to Treatment shorter Antibiotic Courses for kids’ UTIs: New Research & Guidelines The Evolving Landscape of Pediatric UTI Treatment What the Latest Research Shows understanding Uncomplicated UTIs in Children Diagnosing a UTI … Read more
TOPLINE: In children with febrile urinary tract infections (UTIs), individualised antibiotic treatment stopping at 3 days after the achievement of adequate clinical improvement compared with the standard 10-day treatment regimen increased the risk for recurrent infections but reduced antibiotic use and the number of days of adverse events. METHODOLOGY: Researchers conducted a pragmatic trial (INDI-UTI) … Read more
TOPLINE: Janus kinase (JAK) inhibitors were associated with more infections, particularly herpes infections, in patients with atopic dermatitis (AD) compared with biologics, in a cohort study. METHODOLOGY: A prospective, multicenter observational study included 1793 patients (age, ≥ 12 years) with moderate to severe AD from the Dutch BioDay registry between October 2017 and July 2024. … Read more
TOPLINE: Low levels of soluble neuropilin-1 (sNRP-1) were associated with depression in patients with newly diagnosed type 2 diabetes (T2D), with the association remaining consistent across all age groups. METHODOLOGY: The NRP-1 receptor is an essential transmembrane glycoprotein involved in the development of the nervous and cardiovascular systems, as well as immune regulation, and may … Read more
TOPLINE: Most survey respondents were unaware of US Food and Drug Administration (FDA)-approved treatments for hidradenitis suppurativa (HS), and only 18% were satisfied with their current management. METHODOLOGY: Researchers developed a survey that was distributed via the HSconnect.org listserv between November and December 2023, collecting responses from participants aged ≥ 18 years with HS. A … Read more
TOPLINE: More than half (56.2%) of patients who are newly diagnosed with lymphoma and myeloma experience clinically significant anxiety or depression symptoms, with lower financial satisfaction and medical mistrust increasing anxiety risk. Depression symptoms, present in 27.5% of patients, were linked to significantly lower quality-of-life (QOL) scores. METHODOLOGY: A cross-sectional survey study conducted at Dana-Farber … Read more
TOPLINE: The prevalence of cerebral small vessel disease (CSVD) nearly doubled over 7.5 years in neurologically asymptomatic patients with type 1 diabetes (T1D). The progression of cerebral microbleeds (CMBs), one of the manifestations of CSVD, was associated with baseline systolic blood pressure and A1c among other factors, while the progression of white matter hyperintensities was … Read more
TOPLINE: Point-of-care urine dipstick demonstrated higher sensitivity (90.2%) and specificity (92.6%) than laboratory urinalysis for diagnosing urinary tract infection (UTI) in febrile infants aged 2-6 months. The findings suggested laboratory urinalysis may not be necessary for initial treatment decisions. METHODOLOGY: A cross-sectional analysis included 9387 previously healthy infants aged 2-6 months who presented with fever … Read more
AI Predicts Premature Death in IBD Patients: A Call for Multidisciplinary Care Table of Contents AI Predicts Premature Death in IBD Patients: A Call for Multidisciplinary Care The Alarming Reality of Premature Death in IBD Patients Understanding the Scope of the Problem in the U.S. Key Findings: Unveiling the Predictors of Premature Death A Call … Read more
TOPLINE: Maintaining a healthy diet and a lower waist-to-hip ratio (WHR) throughout midlife was associated with improved brain health and cognitive function in older age in a new cohort study. METHODOLOGY: Researchers analyzed data from the Whitehall II Study (inception: 1985) at University College London, London, and the Whitehall II Imaging Substudy (2012-2016) at the … Read more