TOPLINE: Among women aged 70 years or older with screen-detected breast cancer, those with a history of screening mammography within 5 years of their diagnosis were much more likely to be diagnosed at an earlier stage and much less likely to die from breast cancer, according to a new analysis of over 13,000 women. METHODOLOGY: … Read more
Archyde Expert Groups Advocate for Refined Approach to Diagnosing Indolent prostate Cancer May 8, 2025 Two leading international pathology societies are urging a shift in how indolent prostate cancers are detected and diagnosed, aiming to reduce overtreatment and improve patient outcomes. Teh Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP) recently … Read more
The American Society of Clinical Oncology (ASCO) has released updated guidelines to guide fertility preservation for people with cancer, with the previous update published in 2018. The 2025 update reflects substantial growth in the evidence base, with 166 studies incorporated compared with just 61 studies in the 2018 guidelines. According to the authors, this expanded … Read more
TOPLINE: A review of the distribution of risk estimates from three commonly used genomic assays for breast cancer found that Black women were more likely to have aggressive tumor phenotypes, which contributed to poorer outcomes. Such disparities persisted after adjusting for genomic risk scores and tumor subtypes. While these tests remain valuable for guiding treatment … Read more
Editor’s Note:The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians, but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions. If you have a case that you would like to suggest for a future Case Challenge, … Read more
Investigators in Canada have discovered that molecular changes to an infectious bacterium (Group A Streptococcus pyogenes [GAS]) underlie a post-pandemic surge of coinfections with a respiratory diagnosis, prompting one expert to suggest lockdowns during the pandemic might have created an immunity deficiency in hosts while at the same time helping the bacteria create newly virulent … Read more
Even though older adults are more likely to be diagnosed with colorectal cancer (CRC), there is a concerning rise in diagnoses among younger adults, making it essential for healthcare providers to educate adult patients of all ages about the lifestyle-related risk factors associated with the disease. Many are familiar with the modifiable risk factors of … Read more
Children aged 6 months to 12 years are the main spreaders of respiratory syncytial virus (RSV) infections within their households, based on data from more than 3000 individuals. Previous studies have suggested that household transmission of RSV may contribute to community spread, but data on transmission of the virus within households are limited, wrote Sarah … Read more
TOPLINE: Late amniocentesis demonstrates a 22.9% overall genetic diagnostic yield, with 2.4 times higher yield for fetuses with multiple organ system anomalies (36.4%) vs single organ system anomalies (15.3%). The procedure shows a low 1.2% complication rate, with delivery occurring at a median of 38 weeks 3 days gestation. METHODOLOGY: Researchers established a collaborative network … Read more
BOSTON — Patients with non-BRCA gene mutations undergoing risk-reduction surgery to prevent tubo-ovarian cancers showed no signs of tubo-ovarian high-grade serous carcinoma or serous tubal intraepithelial carcinoma compared with about 3% incidence of these carcinomas in patients with BRCA mutations in a multi-center study. “We need to define the role of risk-reduction surgery in reducing … Read more