Ion Channel

New review reveals complex polygenic architecture underlying common epilepsies

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An insightful mini-review published in Genomic Psychiatry synthesizes the rapidly expanding landscape of molecular genetic research on common epilepsies, assembling evidence from genome-wide association studies, whole-exome sequencing projects, and advanced statistical modeling to illuminate the polygenic architecture that underpins these heterogeneous neurological disorders. The synthesis, led by Dr. Olav B. Smeland of the Centre for … Read more

Ion channel TRPV4 found to regulate relief after scratching an itch

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When you scratch an itch, something tells your brain when to stop. That moment of relief, when scratching feels “enough,” is not accidental. Scientists have now identified a key molecular and neural mechanism behind this built-in braking system, shedding new light on how the body regulates itch and why this control fails in chronic conditions. … Read more

New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

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Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer’s disease. At the heart of this condition lies the dysfunction of pancreatic islets, the mini-organs called organoids responsible for regulating blood sugar, in both autoimmune type 1 diabetes and stress-induced type 2 diabetes. … Read more

Discovery reveals how neuronal ion channels store molecular memory

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Researchers have discovered how an ion channel in the brain’s neurons has a kind of ‘molecular memory’, which contributes to the formation and preservation of lifelong memories. The researchers have identified a specific part of the ion channel at which new drugs for certain genetic diseases could be targeted. The study, led from Linköping University … Read more

How fruit fly genetics could change the fight against mosquito diseases

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Silencing Mosquito Matings: A New Strategy to Limit Disease Spread Female fruit flies, with their agile antennae, are nature’s master detectives of sound. They "hear" the distinctive wing beats of males of their species, pairing up in a dance as old as evolution itself. Now, a remarkable discovery by University of Iowa researchers hints at … Read more