A team of researchers from NYU Abu Dhabi and the University of Denver have identified a promising small molecule that could help slow or halt the progression of serious brain diseases such as Parkinson’s disease, offering new hope for treatments that go beyond managing symptoms. These diseases, which also include Lewy body dementia and multiple … Read more
Four years ago, a research group at the University of Oslo made what would turn out to be a major discovery. They found that an extract from passion fruit had the potential to slow the development of Alzheimer’s disease. What is it about this small fruit that might promote healthy ageing and slow the progression … Read more
Optibrium, a leading developer of software and AI solutions for molecular design, today announced a new QuanSA™ plugin for PyMOL, providing an intuitive Graphical User Interface (GUI) for its ligand-based binding affinity prediction method, part of the Company’s BioPharmics 3D molecular modelling platform. The new interface facilitates chemists’ access to accurate affinity predictions that guide … Read more
After a heart attack, cardiologists can reopen blocked vessels and restore blood flow, but the muscle cells that died will never be replaced. “The heart is one of the organs with the least ability to regenerate,” said Ke Cheng, Alan L. Kaganov Professor of Biomedical Engineering at Columbia Engineering. “The spontaneous regeneration power is very, very limited.” In … Read more
Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data … Read more
Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole cell type in articular cartilage, survive in a low-oxygen environment by relying heavily on glycolysis, producing large amounts of lactate. While lactate has traditionally been associated with tissue stress and inflammation, emerging evidence suggests it also functions … Read more
A sweeping Lancet review reveals how modern incretin-based drugs are reshaping treatment for obesity and diabetes, delivering powerful weight loss while simultaneously protecting the heart, kidneys, and metabolic health. Review: GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. Image Credit: Gecko Studio / Shutterstock In a recent review published in The … Read more
New research suggests that zinc does far more than support immunity, revealing intricate molecular switches that may influence how the heart responds to inflammatory injury. Review: Zinc: A metallic shield against cardiac inflammation. Image Credit: Cagkan Sayin / Shutterstock In a recent review published in the journal Metallomics, researchers synthesized a broad body of mechanistic and … Read more
Messenger RNA (mRNA) technology is transforming medicine by providing our cells with genetic instructions to produce proteins that help the immune system prevent or fight a wide range of diseases, including cancer and other rare disorders. Before the molecule can help fight disease, mRNA is packaged into lipid nanoparticles to protect it from rapid degradation. … Read more
Scientists at Gladstone Institutes have flipped the traditional approach to finding potential treatments for deadly diseases. Instead of starting with a disease and hunting for a cure, they began with vitamins and systematically identified genetic diseases that could benefit from high-dose supplements. Using this framework, the team discovered that vitamin B3 supplementation, when tested in … Read more