BOSTON — Sparsentan, a first-in-class, oral dual endothelin-angiotensin receptor antagonist, shows significant benefit in reducing proteinuria in the difficult-to-manage focal segmental glomerulosclerosis (FSGS) compared with the angiotensin II receptor blocker (ARB) irbesartan, a new post-hoc analysis of the phase 3 DUPLEX trial shows. “Dual endothelin angiotensin receptor blockade with sparsentan led to partial or complete … Read more
New UCLA research conducted using mouse models and human genetic data has uncovered a critical factor that determines how much scarring occurs following kidney injury, leading scientists to identify a potential precision medicine approach to prevent chronic kidney disease progression. The study, published in Science Translational Medicine, highlights the role of type 5 collagen – … Read more
A MUM has told how proud she is that her daughter will save lives after her shock death. Olivia Farrell lost her daughter Lauren, 24, following a heart attack in 2022. 3 Olivia Farrell spoke to Ireland AM about her daughter’s sudden passingCredit: Facebook 3 Lauren suffered a heart attack in 2022Credit: Facebook 3 Lauren’s … Read more
For a disease afflicting 35.5 million people in the US, chronic kidney disease flies under the radar. Only half the people who have it are formally diagnosed. The consequences of advanced chronic kidney disease are severe. When these essential organs can no longer do their job of filtering waste products from the blood, patients need … Read more
With efforts underway to expand access to the kidney transplant waiting list to more patients, including many with end-stage kidney disease (ESKD), new research underscored the corresponding significant increase in the number of donor organs needed to prevent increased waiting periods for patients. “We found that expanding the transplant waiting list would result in longer … Read more
Updates on chronic kidney disease (CKD) diagnosis, use of sodium–glucose cotransporter-2 (SGLT-2) inhibitors as first-line therapy, and personalized treatment approaches for kidney and cardiovascular risk reduction are among the new CKD management recommendations from the Kidney Disease: Improving Global Outcomes (KDIGO) organization. “The last CKD guideline was published in 2012, and there have been so … Read more
Three months after her breakthrough surgery at NYU Langone Health, Towana Looney, the longest-living recipient of a genetically engineered pig kidney, is headed back home to Alabama. “I feel blessed,” said the 53-year-old grandmother. “I’m so grateful to be alive and thankful to have received this incredible gift. It couldn’t have happened without God and … Read more
A global study on prostate and testicular cancers reveals rising prevalence and incidence but declining mortality, highlighting the need for targeted healthcare strategies. Study: Global burden and risk factors of male cancers from 1990 to 2021, with forecasts to 2040. Image Credit: Julien Tromeur / Shutterstock Prostate and testicular cancers are growing concerns for men’s health worldwide. … Read more
Don’t Self-Medicate: expert Warns of Serious Risks A prominent critical care specialist is urging Americans to avoid self-medicating, emphasizing the potential for severe health consequences. Dr. Hossam Mowafy, a professor at Kasr Al-Aini Faculty of Medicine, recently highlighted the dangers of taking medication without a doctor’s prescription, especially for individuals wiht certain health conditions. Dr. … Read more