metastatic cancer

Can Adding Radium-223 to RT Boost Prostate Cancer Outcomes?

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TOPLINE: Adding radium-223 dichloride (Ra223) to metastasis-directed stereotactic ablative radiotherapy (SABR) did not improve progression-free survival compared with SABR alone in men with bone-only oligometastatic castration-sensitive prostate cancer, according to a phase 2 trial. However, the authors identified two potential prognostic biomarkers — high-risk DNA mutations and T-cell receptor repertoire diversity — to predict progression-free … Read more

Breast-Conserving Tx, Mastectomy Have Similar Outcomes

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TOPLINE: In a multicenter cohort study of 575 South Korean patients with BRCA1 or BRCA2 pathogenic variants, breast-conserving treatment demonstrated comparable oncologic outcomes to mastectomy over a median follow-up of 8.3 years. After propensity score matching, no significant differences between the two surgical approaches were found in terms of locoregional recurrence, distant recurrence, and overall … Read more

Immunotherapy Insights and Research in Endometrial Cancer

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This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Ursula A. Matulonis, MD: Hello. I’m Dr Ursula Matulonis. Welcome to season 2 of the Medscape InDiscussion Endometrial Cancer podcast series. I am honored to have as … Read more

Biomarkers Offer Clues to Prognoses in Lung Adenocarcinoma

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BOSTON — Key DNA and chromosomal and immune cell changes in early-stage lung adenocarcinoma show significant associations with outcomes, representing potentially important early predictors to guide management of the increasingly prevalent, deadly disease, according to the results of a new study. “We found that DNA ploidy and chromosomal structure predict early recurrence in lung adenocarcinoma, … Read more

Low-Dose Apixaban Best for Long-Term Use in Cancer

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CHICAGO — Extended therapy with reduced-dose apixaban is just as effective as the high dose in preventing recurrent venous thromboembolism (VTE) in patients with active cancer who completed at least 6 months of anticoagulant treatment after a clot, and results in a lower rate of clinically relevant bleeding, the API-CAT trial shows. “Our results indicate … Read more

Adjuvant Chemo vs Radiotherapy Alone in Cervical Cancer

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New findings on radiation plus adjuvant chemotherapy in patients with intermediate-risk cervical cancer seem to spell the end for the dual therapy in this group.  Results from a phase 3 clinical trial of 316 women who’d had radical hysterectomies found that adjuvant chemotherapy as treatment for their early-stage, intermediate-risk cervical carcinoma did not improve outcomes … Read more

Prostate Cancer Patient Develops Rare Penile Metastases

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Key Takeaways For men with genitourinary malignancies, such as prostate cancer, examining the external genital area is essential. While this may seem routine, it remains a crucial recommendation, as illustrated by the case of a patient reported by Portuguese physicians led by José Laert from the Department of Radiology, Hospital CUF Tejo, Lisbon, Portugal. The … Read more

Brain Metastasis Patterns Affect Breast Cancer Survival

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TOPLINE: In patients with ERBB2-positive metastatic breast cancer (ERBB2+ MBC) and brain metastasis, more than half of deaths were due to central nervous system (CNS)–related causes; however, patients with CNS-only metastasis have significantly longer overall survival than those with both CNS and extracranial metastasis. METHODOLOGY: About one third of patients with ERBB2+ MBC develop brain … Read more

How New Research Is Redefining Melanoma Treatment

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The treatment landscape for melanoma saw significant advancements in 2024, as highlighted by Elisa Funck-Brentano, MD, PhD, from Ambroise-Paré Hospital in Paris, France, during her presentation at the 2024 Dermatology Days of Paris conference in Paris. Checkpoint Inhibitors in Neoadjuvant Therapy The standard approach for treating resectable stage III melanoma with locoregional metastases has traditionally … Read more

NECTORS for Advanced HPV-Related Head and Neck Cancer?

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TOPLINE: Compared with standard concurrent chemoradiation, neoadjuvant chemotherapy followed by transoral robotic surgery (NECTORS) and neck dissection led to superior distant metastasis-free and overall survival outcomes in patients with advanced human papillomavirus–related oropharyngeal squamous cell carcinoma (HPV-OPSCC). METHODOLOGY: Distant metastasis is a leading cause of death in patients with HPV-OPSCC, and standard of care concurrent … Read more