Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering receptor expressed on myeloid cells 2 (TREM2) … Read more
A novel nasal booster approach may help close the gap between systemic vaccination and infection-blocking mucosal immunity, offering fresh insight into next-generation COVID vaccine strategies. Study: Intranasal booster drives class switching and homing of memory B cells for mucosal IgA response. Image Credit: Jo Panuwat D / Shutterstock Current intramuscular vaccines excel at eliciting blood-based … Read more
John Leonard, MD John Leonard, MD, of Weill Cornell Medicine, New York City, has built a devoted following for his “Leonard List” — previews of research to be presented at annual American Society of Hematology (ASH) meetings that are held every December. For example, in November 2024, in the days leading up to ASH 2025, … Read more
People with vasculitis may need at least three or four vaccinations for COVID-19 before they start to show an immune response against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, new research has suggested. In a longitudinal retrospective study, serum antibody neutralization against the Omicron variant of the virus and its descendants was found to … Read more
After combing through 4,000 existing medications, an artificial intelligence tool helped uncover one that saved the life of a patient with idiopathic multicentric Castleman’s disease (iMCD). This rare disease has an especially poor survival rate and few treatment options. The patient could be the first of many to have their lives saved by an AI … Read more
A clinical trial supported by the National Institutes of Health (NIH) is testing an experimental treatment designed to help people suffering the effects of dengue, a mosquito-borne viral disease. The study is supported by NIH’s National Institute of Allergy and Infectious Diseases (NIAID), and will involve exposing adult volunteers to a weakened strain of dengue … Read more
TOPLINE: The use of valaciclovir as prophylaxis prevents herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE) receiving anifrolumab treatment, with no cases of zoster reported during the follow-up period in patients receiving valaciclovir. METHODOLOGY: Anifrolumab, a human monoclonal antibody binding to type I interferon receptor subunit 1, increases the risk for HZ in … Read more