RNA Sequencing

APOE4 alters brain immunity and cognition differently in females and males

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A new study shows that APOE4 reshapes brain-linked immune and lymphatic pathways in strikingly different ways in females and males, with opposite cognitive effects when innate immunity is suppressed. Study: Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition. Image Credit: ahmetmapush / Shutterstock In a recent study published in the journal Neuron, … Read more

Researchers identify cellular drivers of gut scarring in Crohn’s disease

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As inflamed regions of the gut form scar tissue, the space within the gut lumen becomes smaller and more restricted, leading to symptoms of gut obstruction. There is currently no drug treatment available for this complication – eventually as fibrosis worsens, surgery becomes the only option. The researchers discovered that the biggest build up of … Read more

New HIV-seq tool advances understanding of persistent viral reservoirs

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For people living with human immunodeficiency virus (HIV), life-saving antiretroviral therapy keeps their HIV-infected immune cells from making new copies of the virus, preventing illness and transmission. Historically, these infected cells have been known as the “latent” HIV reservoir-implying that the HIV within the infected cells is completely inactive. But notion that the entirety … Read more

Investigating microglia’s role in Alzheimer’s pathology

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Announcing a new article publication for BIO Integration journal. Alzheimer’s disease (AD) is a neurodegenerative disorder and the leading cause of dementia worldwide. Microglia, as central nervous system (CNS) resident macrophages, are key to AD pathology. Indeed, microglia aggregation around amyloid-β (Aβ) deposits is an AD hallmark. Triggering receptor expressed on myeloid cells 2 (TREM2) … Read more

Immune scaffold predicts onset weeks early

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A retrievable immune scaffold reveals a 5–7 week presymptomatic window for tracking type 1 diabetes progression, long before blood sugar tests turn positive.  Study: Longitudinal monitoring of type 1 diabetes progression to disease onset. Image credit: Halfpoint/Shutterstock.com A recent study published in Science Advances described the application of subcutaneous microporous scaffolds, viz., immunological niches (INs), for … Read more

Comparing single cell RNA methods to improve gastrointestinal cancer research

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How would you summarize your study for a lay audience? Research on gastrointestinal diseases, especially cancer, has mainly looked at the epithelial cells, which line the surfaces of organs, are important for various functions, and are believed to be the cells that go awry to cause these diseases. However, studying these cells using single-cell RNA … Read more

Hedonic eating fades with obesity—but neurotensin helps bring it back

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New research reveals how fat-rich diets silence the brain’s reward for food—and how a single molecule may reignite the pleasure of eating. Study: Changes in neurotensin signalling drive hedonic devaluation in obesity. Image Credit: StudioMolekuul / Shutterstock In a recent study published in the journal Nature, researchers investigated how a chronic high-fat diet (HFD) affects hedonic feeding behaviors … Read more

Scientists unlock RNA’s hidden power, could supercharge cancer treatment

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Scientists have made a major discovery about ADAR1—a protein that controls RNA-induced immune responses—paving the way for better treatments for autoimmune diseases and cancer immunotherapy. ADAR1 converts adenosine to inosine in double-stranded RNA, a key process for preventing unwarranted immune responses, yet the molecular basis of this editing remained unclear. A research team led by … Read more

Unlocking ADAR1: Groundbreaking Insights Pave Way for Autoimmune and Cancer Therapies

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Breakthrough in RNA Editing: Unveiling the Mysteries of ADAR1 for Enhanced Cancer and Autoimmune Disease Treatments Introduction to ADAR1 and its Importance In a landmark discovery, scientists have… The post Unlocking ADAR1: Groundbreaking Insights Pave Way for Autoimmune and Cancer Therapies appeared first on NewsyList. Source link

Advancements in molecular diagnostics for hematopoietic and lymphocytic neoplasms

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Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases. Traditional classifications rely on morphology, karyotyping, and fluorescence in situ hybridization (FISH). However, recent advancements in next-generation sequencing (NGS) allow simultaneous genetic profiling of multiple genes, enhancing diagnostic precision and … Read more