TOPLINE: Outpatient low-dose initiation (LDI) of buprenorphine has a low rate of success in people with opioid use disorder (OUD) using fentanyl, with a completion rate of just 34% and retention rates of 18%-21%, a new cohort study suggests. METHODOLOGY: The cohort study analyzed data from 126 adults (median age, 35 years; 71% men; 52% … Read more
TOPLINE: Blood pressure (BP) measurements taken in a public space — with and without ambient noise — were minimally different from readings obtained in a private, quiet office. Mean systolic BP varied by less than 1 mm Hg between settings. Although guidelines advise measuring BP in a quiet place, public venues may be valid options … Read more
Archyde > Long-Term Efficacy and Safety of Ritlecitinib in Alopecia Areata Table of Contents 1. Long-Term Efficacy and Safety of Ritlecitinib in Alopecia Areata 2. Promising Results: Hair Regrowth Sustains Over Time 3. Safety Profile: Favorable Despite Side Effects 4. What Are the Key Differences Between the ALLEGRO-LT Study and Previous Ritlecitinib Trials for AA? … Read more
TOPLINE: Ritlecitinib demonstrates long-term improvements in regrowth of scalp hair, eyebrows, and eyelashes at 24 months in adults and adolescents with alopecia areata (AA) and ≥ 25% scalp hair loss. METHODOLOGY: Researchers evaluated outcomes in 449 de novo adult and adolescent patients (mean age, 32.9 years) with AA and ≥ 25% scalp hair loss, enrolled … Read more
The Evolving Landscape of Cannabis and Cognition: What’s Next? Table of Contents The Evolving Landscape of Cannabis and Cognition: What’s Next? Unveiling the Brain’s Response to Cannabis Did You Know? Short-Term Effects and Long-Term Implications Pro Tip: Navigating the Complexities of Cannabis Use the Future of Cannabis Research FAQ Recent research has ignited a crucial … Read more
TOPLINE: Heavy lifetime cannabis use is linked to reduced brain activation during working memory tasks in young adults, while recent use is also associated with reduced activation during cognitive tasks, new research shows. METHODOLOGY: Researchers analyzed data collected between 2012 and 2015 from the Human Connectome Project. The cross-sectional study included more than 1000 young … Read more
TOPLINE: Time-restricted eating (TRE) doesn’t significantly reduce visceral adipose tissue (VAT) but leads to significant reductions in body weight compared with usual care in adults with overweight or obesity. METHODOLOGY: Although previous studies suggest that TRE may lead to modest weight loss and improvements in cardiometabolic health, the optimal timing of the eating window in … Read more
TOPLINE: Performance feedback reduces the time to endovascular thrombectomy (EVT) in patients with ischemic stroke, according to a Dutch study. METHODOLOGY: The researchers conducted a stepped-wedge cluster randomized PERFEQTOS trial in the Netherlands, which included 4747 consecutive adult patients with ischemic stroke who underwent EVT between January 2020 and June 2022. Hospitals started with usual … Read more
Archyde Empagliflozin and Weight Loss: A Promising First-Line Treatment for Diabetes and Prediabetes Table of Contents 1. Empagliflozin and Weight Loss: A Promising First-Line Treatment for Diabetes and Prediabetes 2. Understanding the Study 3. Key Findings 4. What This Means for patients 5. Limitations and Future Directions 6. Conclusion 7. How Does Empagliflozin Contribute to … Read more
TOPLINE: The use of valaciclovir as prophylaxis prevents herpes zoster (HZ) in patients with systemic lupus erythematosus (SLE) receiving anifrolumab treatment, with no cases of zoster reported during the follow-up period in patients receiving valaciclovir. METHODOLOGY: Anifrolumab, a human monoclonal antibody binding to type I interferon receptor subunit 1, increases the risk for HZ in … Read more