Personalized gene editing corrects fatal infant metabolic disorder in world-first treatment

In a global first, scientists have used advanced base editing to repair a deadly gene mutation in a newborn, marking a major leap forward in the treatment of rare inherited metabolic diseases. Study: Personalized Gene Editing to Treat an Inborn Error of Metabolism. Image Credit: Shutterstock AI Generator / Shutterstock.com In a recent New England Journal … Read more

Higher BMI in adolescence worsens genetic risk for high blood pressure, study finds

New research reveals that teens with higher BMI are more likely to experience elevated blood pressure as adults, especially if they have a genetic predisposition—underscoring the need for early weight management to reduce lifelong cardiovascular risks. Study: Body mass index modifies genetic susceptibility to high systolic blood pressure in adolescents and young adults: results from … Read more

Blood immune cells found to impact cancer survival

Immune Snapshot Could Revolutionize Cancer Care A groundbreaking study from UCL and the Francis Crick Institute has revealed a powerful connection between the immune system and cancer survival. Researchers have developed a novel tool called ImmuneLENS, which analyzes the proportion of T cells and B cells in a patient’s blood directly from their whole-genome sequencing … Read more

ImmuneLENS method provides new insights into cancer prognosis

The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique developed by researchers at UCL and the Francis Crick Institute. The tool, described in Nature Genetics, is called Immune … Read more

Stanford researchers identify key variants linked to inherited cancer risk

Thousands of single changes in the nucleotides that make up the human genome have been associated with an increased risk of developing cancer. But until now, it’s not been clear which are directly responsible for the uncontrolled cellular growth that is the hallmark of the disease and which are simply coincidences or minor players. Stanford … Read more

Takumi-shaped DNA hydrogels show promise for targeted therapies

Hydrogels are polymeric materials with three-dimensional network structures containing large amounts of water. They serve as sustained-release drug delivery systems as they can encapsulate various bioactive substances, including drugs, antigens, and even cells. Hydrogels are better drug delivery alternatives than conventional systems, as they are more biocompatible, biodegradable, and easily administered as an injectable scaffold. … Read more