teenage

Centanafadine: New Hope for Adult ADHD?

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Novel non-Stimulant Shows Promise for Adult ADHD: Centanafadine Demonstrates Clinically Meaningful Enhancement Table of Contents Novel non-Stimulant Shows Promise for Adult ADHD: Centanafadine Demonstrates Clinically Meaningful Enhancement Centanafadine Shows Promise in ADHD Treatment: A New Approach to Symptom Management Understanding Centanafadine’s Impact on ADHD Symptoms Expanding the Research: Pediatric Trials Yield Positive Results safety Profile … Read more

Centanafadine ‘Clinically Meaningful’ for Adult ADHD

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LOS ANGELES — The novel norepinephrine, dopamine, and serotonin reuptake inhibitor (NDSRI) centanafadine (Otsuka Pharmaceutical Co., Ltd.) is effective and “clinically meaningful” for adult attention-deficit/hyperactivity disorder (ADHD), new research suggested. In a combined analysis of two phase 3 trials with a total of 859 adults, more patients who received the NDSRI had at least an … Read more

Consider Sex of Both Parent and Child in MetS Screening

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TOPLINE: Parental metabolic syndrome (MetS) had a notable impact on the metabolic health of offspring; paternal MetS showed stronger associations with several metabolic markers in boys, whereas maternal MetS was linked to elevated triglyceride levels in both sexes but affected other markers, primarily in boys. METHODOLOGY: Multiple studies have examined the influence of parental MetS … Read more

Vitiligo Study Identifies Three Patient Burden Profiles

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TOPLINE: A recent study identified three clinically distinct vitiligo profiles on the basis of Vitiligo Patient Priority Outcomes (ViPPO) responses from real-world patient data. Classes with more severe emotional and social functioning impacts had more severe disease per physician assessment, visible areas of lesion involvement, and work productivity and quality-of-life (QoL) impairment. METHODOLOGY: Researchers collected … Read more

ADHD Medications and Cardiovascular Effects: New Data

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A new systematic review and network meta-analysis showed few differences in the cardiovascular (CV) effects of stimulants and noradrenaline reuptake inhibitors used to treat attention-deficit/hyperactivity disorder (ADHD). Short-term use of amphetamines, atomoxetine, lisdexamfetamine, methylphenidate, and viloxazine was associated with small increases in blood pressure (BP), pulse, or both in children, adolescents, and adults. Further, the … Read more

Canadian Pediatricians Ill Prepared to Treat Drug Overdoses

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Illicit drug toxicity is an “escalating public health emergency” in Canada that significantly affects adolescents, yet pediatricians are ill prepared to manage it, new research suggested. A study of more than 1000 pediatricians in Canada who care for young people aged 12-18 years found that while close to 14% reported caring for at least one … Read more

Infections Higher With JAK Inhibitors in Eczema Study

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TOPLINE: Janus kinase (JAK) inhibitors were associated with more infections, particularly herpes infections, in patients with atopic dermatitis (AD) compared with biologics, in a cohort study. METHODOLOGY: A prospective, multicenter observational study included 1793 patients (age, ≥ 12 years) with moderate to severe AD from the Dutch BioDay registry between October 2017 and July 2024. … Read more

The Chronic Disease With No Clinical Classification

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Is obesity among the most misunderstood, misclassified, and mistreated diseases? Over the past 30 years, researchers have not only identified a key hormone (leptin) that helps regulate appetite and body weight, but they’ve also determined the biologic underpinnings (eg, altered central nervous system pathways associated with energy balance) and discovered that obesity is often genetically … Read more

‘Paracetamol Challenge’ Risks Fatal Consequences for Teens

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The French National Agency for the Safety of Medicines and Health Products has alerted healthcare professionals and parents about a concerning trend known as the “Paracetamol Challenge” that is gaining popularity, particularly on social media, among children and adolescents. This challenge involves the deliberate ingestion of toxic doses of paracetamol to evaluate one’s resistance and … Read more

Sleep Med Prescriptions Surge Among Children Post-COVID

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TOPLINE: During the COVID-19 pandemic, prescriptions for hypnotic medications notably increased among children, particularly among those aged between 6 and 11 years for prolonged-release melatonin and in adolescents for Z-drugs such as zolpidem; this increase persisted until the end of the study in December 2023. METHODOLOGY: Researchers conducted a cross-sectional analysis of national dispensing data … Read more