In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses. Lymph nodes are highly organized command centers of the immune system. Within these structures, immune cells … Read more
A research team from POSTECH and ImmunoBiome in Korea, led by Professor Sin-Hyeog Im, has uncovered a new mechanism showing how butyrate-a short-chain fatty acid produced by gut commensal bacteria-enhances T follicular helper (Tfh) cell activity to promote antibody production and strengthen mucosal vaccine efficacy. This study identifies a new microbiota–immune–antibody production axis linking microbial metabolism … Read more
Gut microbiota may be the key factor explaining why certain individuals do not respond well to the pneumococcal vaccine-a bacterium that can cause various diseases, such as pneumonia. This conclusion is drawn from a recent study led by the B Cell Biology Research Group at the Hospital del Mar Research Institute, published in Science Advances. … Read more
A recent study by Emory University researchers provides new insights into why the mRNA vaccines developed to fight COVID-19 in 2021 are less effective in patients with autoimmune diseases. By providing insights into the cellular processes behind that lessened protection, the new study published in Nature Immunology, highlights that lupus patients may require tailored vaccination … Read more