Pereira, F. A., Qiu, Y., Zhou, G., Tsai, M. J. & Tsai, S. Y. The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. Genes Dev. 13(8), 1037–1049 (1999). Google Scholar Pereira, F. A., Qiu, Y., Tsai, M. J. & Tsai, S. Y. Chicken ovalbumin upstream promoter transcription factor (COUP-TF): Expression during mouse … Read more
Ferlay, J. et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur. J. Cancer 103, 356–387 (2018). Google Scholar Thorstenson, A. et al. Tumour characteristics and surgical treatment of renal cell carcinoma in Sweden 2005–2010: A population-based study from the national Swedish kidney cancer register. … Read more
In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses. Lymph nodes are highly organized command centers of the immune system. Within these structures, immune cells … Read more
A new LMU study shows how proteins function reliably even without a stable 3D structure – and the crucial importance not only of short sequence motifs, but also of the chemical characteristics. Many proteins do not only consist of stably folded components. They also contain flexible parts known as intrinsically disordered regions (IDRs), which do … Read more
World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report: 2022. https://www.who.int/publications/i/item/9789240062702 (2022). World Health Organization. WHO Updates List of Drug-Resistant Bacteria Most Threatening to Human Health. https://www.who.int/publications/i/item/9789240038608 (2024). Krawczyk, B., Wityk, P., Gałęcka, M. & Michalik, M. The many faces of Enterococcus spp.-commensal probiotic and opportunistic pathogen. Microorganisms 9, 1900 (2021). Google … Read more
Choudhary, B., Chauhan, O. P. & Mishra, A. Edible seaweeds: a potential novel source of bioactive metabolites and nutraceuticals with human health benefits. Front Mar. Sci 8, 740054 (2021). Mishra, A. Algal Functional Foods and Nutraceuticals: Benefits, Opportunities, and Challenges (Bentham Science, 2022). Baghel, R. S. et al. Rehashing our insight of seaweeds as a … Read more
A new international study published in Nature has identified albumin, the most abundant protein in human blood, as a powerful and previously unrecognized defense against mucormycosis, a rare but often fatal fungal infection. The research was led by George Chamilos, MD and his laboratory at the University of Crete and Institute of Molecular Biology and Biotechnology, with critical contributions from a Lundquist Institute for Biomedical … Read more
The cancer gene MYC camouflages tumors by suppressing alarm signals that normally activate the immune system. This finding from a new study offers a promising way to improve existing cancer therapies as well as develop new ones. Could this mark a shift in how we think about cancer therapy? At least in the laboratory, evidence … Read more
A multidisciplinary team has uncovered a key mechanism that allows the human bacterium Mycoplasma pneumoniae-responsible for atypical pneumonia and other respiratory infections-to obtain cholesterol and other essential lipids directly from the human body. The discovery, published in Nature Communications, was co-led by Dr. Noemí Rotllan, from the Sant Pau Research Institute (IR Sant Pau) and … Read more
Researchers at Karolinska Institutet have developed a method that shows how the nervous system and sensory organs are formed in an embryo. By labeling stem cells with a genetic ‘barcode’, they have been able to follow the cells’ developmental journey and discover how the inner ear is formed in mice. The discovery, published in Science, … Read more