Carcinoma

Can Adding Radium-223 to RT Boost Prostate Cancer Outcomes?

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TOPLINE: Adding radium-223 dichloride (Ra223) to metastasis-directed stereotactic ablative radiotherapy (SABR) did not improve progression-free survival compared with SABR alone in men with bone-only oligometastatic castration-sensitive prostate cancer, according to a phase 2 trial. However, the authors identified two potential prognostic biomarkers — high-risk DNA mutations and T-cell receptor repertoire diversity — to predict progression-free … Read more

‘I Forgot I Was 7000 Miles Away’ During Surgical First

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On a cold Wednesday morning in January, Ruben Olivares, MD, sat down at a computer workstation in Cleveland to perform surgery on a man with prostate cancer. Olivares, a urologist at Cleveland Clinic, Cleveland, directed a robot to send high-intensity, focused ultrasound waves to the tumor. But this time, the patient was not in a … Read more

Breast-Conserving Tx, Mastectomy Have Similar Outcomes

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TOPLINE: In a multicenter cohort study of 575 South Korean patients with BRCA1 or BRCA2 pathogenic variants, breast-conserving treatment demonstrated comparable oncologic outcomes to mastectomy over a median follow-up of 8.3 years. After propensity score matching, no significant differences between the two surgical approaches were found in terms of locoregional recurrence, distant recurrence, and overall … Read more

Blocking LSD1 restores immune response in early oral cancer

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Oral squamous cell carcinoma (OSCC) is a leading cause of cancer-related deaths, and early detection is key to improving patient outcomes. However, the mechanisms driving the transition from preneoplastic lesions to full-blown cancer are not well understood. Previous research has primarily targeted advanced OSCC, overlooking the early stages of tumor progression. The new study focuses … Read more

Uterine Cancer Survival Varies Widely by Race Across US

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TOPLINE: A study of 162,500 patients with uterine cancer found that survival rates varied significantly by race and geographic location, with Black patients experiencing the worst survival outcomes in areas with high and low overall diversity. METHODOLOGY: Despite known racial and ethnic disparities in uterine cancer survival in the United States, data on the association … Read more

Do Mammograms Improve Breast Cancer Outcomes in Older Women?

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TOPLINE: Among women aged 70 years or older with screen-detected breast cancer, those with a history of screening mammography within 5 years of their diagnosis were much more likely to be diagnosed at an earlier stage and much less likely to die from breast cancer, according to a new analysis of over 13,000 women. METHODOLOGY: … Read more

Emerging Biomarkers and Treatments in Anal Cancer

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This transcript has been edited for clarity. Hello, my name is Van Morris. I’m a medical oncology physician at MD Anderson Cancer Center who takes care of patients with lower GI cancers. I’m excited to talk today about updates in anal cancer. Anal cancer is a rare cancer linked to prior infection with the human … Read more

Study Maps How Exosomes Hijack Blood Formation

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TOPLINE: Chronic lymphocytic leukemia (CLL) cell–derived exosomes demonstrated the ability to alter healthy donor cell function and suppress normal blood cell formation. These particles affected monocytes, fibrocytes, and lymphocytes, leading to changes in gene expression and protein levels that may contribute to disease progression. METHODOLOGY: Researchers examined CLL cell–derived exosomes and their effects on healthy … Read more

Improved Treatment for Low-Grade PC Lesions

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Archyde Expert Groups Advocate for Refined Approach to Diagnosing Indolent prostate Cancer May 8, 2025 Two leading international pathology societies are urging a shift in how indolent prostate cancers are detected and diagnosed, aiming to reduce overtreatment and improve patient outcomes. Teh Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP) recently … Read more

When Do Brain Metastases Strike in Breast Cancer Care?

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TOPLINE: In patients with metastatic breast cancer (BC), the prevalence of brain metastases increased with each treatment line, rising the most among patients with hormone receptor (HR)–negative, human epidermal growth factor receptor 2 (HER2)–positive disease and the least among those with HR-positive, HER2-negative disease. METHODOLOGY: Brain metastases indicate a poor prognosis in patients with metastatic … Read more