Carcinoma

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

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Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea’s role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.  Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and … Read more

Researchers analyze the mutational landscape of TMB-high colorectal cancer tumors

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Colorectal cancer (CRC), a type of cancer that affects the large intestine and rectum, is one of the leading causes of cancer-related deaths worldwide. The mutational landscape of CRC is well characterized, revealing key pathogenic genetic abnormalities that drive carcinogenesis (cancer development) and disease progression. Moreover, a step-wise colorectal carcinogenesis model has been proposed wherein … Read more

Risk Patterns Guide Surveillance Colonoscopy Decisions

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TOPLINE: A new study revealed that patients with high-risk findings at both baseline and first surveillance colonoscopy (SC1) had a significantly higher risk for colorectal cancer (CRC) than the general population, requiring a second surveillance visit. Conversely, those with low-risk findings at SC1 did not require a second surveillance visit, regardless of their baseline findings. … Read more

New ASCO Guidelines for Fertility Preservation in Cancer

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The American Society of Clinical Oncology (ASCO) has released updated guidelines to guide fertility preservation for people with cancer, with the previous update published in 2018. The 2025 update reflects substantial growth in the evidence base, with 166 studies incorporated compared with just 61 studies in the 2018 guidelines. According to the authors, this expanded … Read more

Immunotherapy Insights and Research in Endometrial Cancer

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This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Ursula A. Matulonis, MD: Hello. I’m Dr Ursula Matulonis. Welcome to season 2 of the Medscape InDiscussion Endometrial Cancer podcast series. I am honored to have as … Read more

Genomic Test Findings for Black Women With Breast Cancer

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TOPLINE: A review of the distribution of risk estimates from three commonly used genomic assays for breast cancer found that Black women were more likely to have aggressive tumor phenotypes, which contributed to poorer outcomes. Such disparities persisted after adjusting for genomic risk scores and tumor subtypes. While these tests remain valuable for guiding treatment … Read more

Lung Cancer Screening Lower Than Others

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TOPLINE: A study found that among US adults eligible for lung cancer screening (LCS), the uptake of colorectal cancer (CRC) and breast cancer screening was nearly fourfold higher than LCS. Among those who had never undergone LCS, approximately 60% participated in other cancer screenings — indicating they are reachable and open to preventive health services. … Read more

Cancer Deaths Fall in Europe, but Not Across All Types

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Cancer statistics in Europe are encouraging: Between 1989 and 2025, nearly 7 million deaths were averted in the European Union (EU), including over 373,000 from breast cancer. This finding emerged from a study recently published in the Annals of Oncology by a team of researchers led by Carlo La Vecchia from the University of Milan … Read more

Can Dx Take a Toll on Mental Health?

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TOPLINE: More than half (56.2%) of patients who are newly diagnosed with lymphoma and myeloma experience clinically significant anxiety or depression symptoms, with lower financial satisfaction and medical mistrust increasing anxiety risk. Depression symptoms, present in 27.5% of patients, were linked to significantly lower quality-of-life (QOL) scores. METHODOLOGY: A cross-sectional survey study conducted at Dana-Farber … Read more

Radiotherapy for Prostate Cancer: What Approach Works Best?

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TOPLINE: Moderately hypofractionated radiotherapy, both isodose and dose-escalated, led to progression-free survival outcomes similar to that achieved with conventionally fractionated radiotherapy in patients with prostate cancer, but the dose-escalated regimen came with an increased risk for toxicities compared with the conventional approach, according to findings from a recent meta-analysis. METHODOLOGY: Moderately hypofractionated radiotherapy is now … Read more