The teratogenic risk of antiepileptic drugs (AEDs) has been a major concern in pharmacovigilance over the past several decades. However, neurodevelopmental and autism-related risks associated with these medications have gradually emerged. Although international registries provide information, they are not sufficiently comprehensive to fully assess the risks posed by many AEDs introduced in the past 20 … Read more
Archyde Maternal Stress During Pregnancy Molecularly Reprograms Newborns, Study Finds April 18, 2025 A groundbreaking study reveals that stress experienced by mothers during pregnancy can induce molecular changes in newborns’ stress response systems. The research highlights significant differences in how male and female babies are affected. Scientists found that maternal stress altered entire families of … Read more
Summary: New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in substance use disorders (SUDs). By limiting expression of Scn4b, HDAC5 reduces the excitability of neurons in the brain’s reward system, weakening the formation of … Read more
Archyde Amyloid Proteins: More Than Just AlzheimerS Culprits? Unraveling Epigenetic Inheritance in Worms Table of Contents 1. Amyloid Proteins: More Than Just AlzheimerS Culprits? Unraveling Epigenetic Inheritance in Worms 2. Epigenetics: Beyond teh DNA Sequence 3. The Curious Case of the *MSTR*-Knockout Worms and amyloid Proteins 4. The Promise and Peril of Amyloid Research 5. … Read more
Researchers at City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, have found that cell mutations are necessary but not always sufficient for tumors to form. Instead, … Read more
A new study explores how epigenetic markers-chemical modifications that influence gene activity-can help predict the risk of developing cardiometabolic diseases and guide personalized prevention strategies. The findings are particularly significant as the prevalence of major cardiometabolic risk factors such as hypertension, diabetes, and obesity continues to rise despite advancements in healthcare and treatment. This trend … Read more
A person’s lifetime risk for cancer may begin before they are even born, reports a paradigm-shifting study by Van Andel Institute scientists. The findings, published in Nature Cancer, identified two distinct epigenetic states that arise during development and are linked to cancer risk. One of these states is associated with a lower lifetime risk while … Read more
A little-known mouse protein disrupts cancer-causing chemical changes to genes associated with human colorectal cancer cells and potentially could be used to treat solid tumors, according to a new study from researchers at the Johns Hopkins Kimmel Cancer Center and the Chinese Academy of Sciences. In the study, published Jan. 8 in the journal Nature … Read more