TOPLINE: Oral lamivudine, an inflammasome inhibitor originally approved for suppressing HIV, was a relatively safe and effective treatment for improving visual acuity in adults with center-involving diabetic macular edema, a serious complication of diabetic retinopathy. METHODOLOGY: Researchers conducted a clinical trial to assess the effectiveness of oral lamivudine vs placebo in improving visual acuity in … Read more
Predicting hyperlipidemia in people living with HIV (PLWH) may have become easier with new research indicating that machine learning is capable of predicting hyperlipidemia in those who have been taking highly active antiretroviral therapy (HAART) for 6 months. The study, published in AIDS,1 shows promise in preventing cardiovascular diseases in PLWH. PLWH number approximately 40 … Read more
TOPLINE: A recent study found that antiretroviral therapy adherence below 90% was associated with significantly lower odds of viral suppression among women living with HIV. METHODOLOGY: Researchers analyzed data from community-based prospective cohort study including women living with HIV across British Columbia, Ontario, and Quebec between 2013 and 2018. Overall, 1187 participants (median age, 42 … Read more
In the long battle to create an effective HIV vaccine, scientists have made a major leap forward. A new study shows that a series of vaccines can coax the immune system to produce powerful antibodies capable of blocking a wide range of HIV strains-including those that are typically the hardest to stop. Published in Immunity … Read more
Eight times more American young adults now take medication to protect them from HIV than a decade ago, a new study finds. But even with this positive news about increasing use of pre-exposure prophylaxis or PrEP, the study also suggests that health care providers and public health agencies could do more to promote consistent use … Read more
Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more
Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more
Young adults and adolescents with HIV have increased risk of developing either a sleep disorder or a mental health issue, according to a new review published in BMJ Open.1 This finding emphasizes the need for interventions in this population to address gaps in care. People living with HIV have consistently been shown to have a … Read more
TOPLINE: Use of nucleoside reverse transcriptase inhibitors (NRTIs), but not other medications for HIV, was associated with a significantly reduced risk for Alzheimer’s disease (AD) in an analysis of two national databases. NRTIs are antiretroviral drugs that block the activation of inflammasome. METHODOLOGY: This study included data of nearly 272,000 US individuals from two national … Read more
Prevention and treatment campaigns are not adequately targeting the particular needs of the 50+ years age group. Indeed, between 2000Â and 2016, the number of adults aged 50Â years and older living with HIV in sub-Saharan Africa doubled. At present, their HIV prevalence is exceeding that of younger adults. By 2040, one-quarter of people living with HIV … Read more