HIV

New insights into HIV-1 capsid disruption open doors for novel therapies

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Announcing a new publication for Acta Materia Medica journal. The HIV-1 capsid protein (CA) plays a crucial role in viral replication by orchestrating nuclear entry through interactions with host nuclear pore complexes (NPCs). Recent research has revealed that HIV-1 CA actively disrupts NPC architecture via phenylalanine-glycine (FG)-repeat nucleoporin interactions, thereby enabling nuclear translocation of viral … Read more

New rifamycin drugs fight antibiotic-resistant lung infections more effectively

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Modified antibiotics beat a stubborn lung pathogen and dodge metabolic landmines, offering new hope for patients with HIV, cystic fibrosis, and TB co-infections. Study: Next-generation rifamycins for the treatment of mycobacterial infections. Image Credit: Kateryna Kon / Shutterstock The rise of drug-resistant bacteria is a major health crisis. Moreover, the development of antibiotic resistance in pulmonary pathogens … Read more

Seroprevalence of HIV, HBV, HCV and Syphilis among blood donors in a Nigerian tertiary medical centre | BMC Infectious Diseases

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The WHO recommends blood collection from voluntary, non-remunerated donors as crucial for ensuring a safe and sufficient blood supply. These donors exhibit a reduced risk of TTIs compared to commercial donors and family replacements. This study documented the prevalence of various TTIs in prospective blood donors at the FMC Azare. In our study, the prevalence … Read more

New Coronavirus Drug Candidates: Promising Research

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A team at UC San Francisco and Gladstone Institutes has developed new drug candidates that show great promise against the virus that causes COVID-19 and potentially other coronaviruses… The post New Coronavirus Drug Candidates: Promising Research appeared first on NewsyList. Source link

What’s Stalling PrEP’s Success in Europe’s HIV Fight – Medscape

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What’s Stalling PrEP’s Success in Europe’s HIV Fight  Medscape Source link

Half-million children could die if U.S. AIDS relief dropped, study says

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The Trump Administration paused all foreign aid funding Jan. 20, ostensibly for a 90-day review and evaluation, with only limited exceptions. Adobe stock/HealthDay Nearly a half-million children could die from AIDS by 2030 if President Donald Trump follows through on plans to cut U.S. relief programs, a new study says. As many as 1 million … Read more

Tulane researchers develop portable device for rapid TB diagnosis

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Tulane University researchers have developed a first-of-its-kind handheld diagnostic device that can deliver rapid, accurate tuberculosis diagnoses in under an hour, according to a study published in Science Translational Medicine. The smartphone-sized, battery-powered lab-in-tube assay (LIT) provides a cost-effective tool that can improve TB diagnoses, particularly in resource-limited rural areas where health care facilities and … Read more

Call for urgent support as US funding cuts threaten HIV/AIDS programs

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Apr 9 2025 In the face of ongoing funding disruptions to US foreign assistance programmes, a group of international experts calls for urgent action to ensure the continuation of life-saving interventions and support for children and families affected by HIV/AIDS in sub-Saharan Africa. The new Health Policy analysis, published in The Lancet, estimates that 1 … Read more

Age-specific relationship between HIV and TB treatment outcomes in the West Region of Cameroon: a cross-sectional study | BMC Infectious Diseases

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Study setting We retrieved information from standard TB registers containing data from TB patients with known HIV status. These patients received treatment at five health facilities (both public and private) across three districts in the West region of Cameroon. The facilities included, Regional Hospital Bafoussam, District Hospital Foumban, District Hospital Dschang, Hôpital St. Vincent de … Read more

Enhanced tuberculosis detection in advanced HIV using stool molecular testing

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The Xpert MTB/Ultra molecular diagnostic test for stool samples, until now recommended only for children, could be established as an additional test for diagnosing tuberculosis in adults living with HIV. This is the main conclusion of the Stool4TB Alliance study, led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by the “la Caixa” Foundation, … Read more