TOPLINE: Low-dose CT screening in a high-risk population detected lung cancer in 2.0% of participants, with nearly 80% of cases diagnosed at stage I or II. The screening protocol demonstrated 97.0% sensitivity at 12 months, with a 4.8% false-positive rate. METHODOLOGY: Annual low-dose CT screening has been recommended in the United States since 2013, but … Read more
BOSTON — Key DNA and chromosomal and immune cell changes in early-stage lung adenocarcinoma show significant associations with outcomes, representing potentially important early predictors to guide management of the increasingly prevalent, deadly disease, according to the results of a new study. “We found that DNA ploidy and chromosomal structure predict early recurrence in lung adenocarcinoma, … Read more
CHICAGO — Extended therapy with reduced-dose apixaban is just as effective as the high dose in preventing recurrent venous thromboembolism (VTE) in patients with active cancer who completed at least 6 months of anticoagulant treatment after a clot, and results in a lower rate of clinically relevant bleeding, the API-CAT trial shows. “Our results indicate … Read more
TOPLINE: A higher body mass index (BMI) across all ages as well as significant weight gain during adulthood were associated with a greater risk for renal cell carcinoma, while a BMI reduction of 10% or more in adulthood, especially after age 50 years, was associated with a lower risk for renal carcinoma, a new study … Read more
Two recent studies have added to the growing body of research suggesting consuming more dairy reduces a person’s risk of getting colorectal cancer. A prospective cohort study in Nature Communications published in January looked at the incidence of colorectal cancer (CRC) in more than 540,000 UK women over 16 years and found a 14% reduced … Read more
BOSTON — Patients with non-BRCA gene mutations undergoing risk-reduction surgery to prevent tubo-ovarian cancers showed no signs of tubo-ovarian high-grade serous carcinoma or serous tubal intraepithelial carcinoma compared with about 3% incidence of these carcinomas in patients with BRCA mutations in a multi-center study. “We need to define the role of risk-reduction surgery in reducing … Read more
Researchers have developed and internally validated a simple score using clinical factors that can help estimate the likelihood of advanced colorectal neoplasia in adults younger than age 45 years. While colorectal cancer (CRC) incidence has declined overall due to screening, early-onset CRC is on the rise, particularly in individuals younger than 45 years — an … Read more
John Leonard, MD John Leonard, MD, of Weill Cornell Medicine, New York City, has built a devoted following for his “Leonard List” — previews of research to be presented at annual American Society of Hematology (ASH) meetings that are held every December. For example, in November 2024, in the days leading up to ASH 2025, … Read more
This transcript has been edited for clarity. As many of us know, there is a therapy for cancer, known as immune checkpoint inhibitors, that in addition to treating cancer can also cause new-onset type 1 diabetes. I’ve always been interested in this because I don’t really understand what’s happening, and also because patients who develop … Read more
New findings on radiation plus adjuvant chemotherapy in patients with intermediate-risk cervical cancer seem to spell the end for the dual therapy in this group. Results from a phase 3 clinical trial of 316 women who’d had radical hysterectomies found that adjuvant chemotherapy as treatment for their early-stage, intermediate-risk cervical carcinoma did not improve outcomes … Read more