Oncogenesis

Tumor-targeted chimeric drug increases efficacy and limits side effects

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Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors at higher doses, while reducing side effects in healthy tissue. An Aurora kinase A (AURKA) inhibitor is viewed as a lethal synthetic … Read more

New insights into therapy resistance in breast cancer

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A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer.” In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow-helping tumors survive, spread, and resist treatment. The review … Read more