compound

Purdue University accelerates rare disease drug discovery with the WELLJET dispenser stacker

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Scientists at Purdue University are using the WELLJET dispenser stacker from INTEGRA Biosciences to increase the speed, consistency and scale of drug screening for rare and neglected parasitic diseases. Integrating automated liquid handling into their workflows has allowed the research team to standardize complex screening assays, improve reproducibility and significantly increase throughput.  Image Credit: Purdue … Read more

Hepatitis C drug may prevent hepatitis E virus replication

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A drug that is already in clinical trials against hepatitis C virus can also prevent hepatitis E virus from replicating. Around 70,000 people die each year from infections with the hepatitis E virus. There is currently neither a vaccine nor a specific drug against this virus. This could change with the identification of bemnifosbuvir as … Read more

BSO mimics anti-obesity effects without causing bone loss in mice

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A new research paper was published in Volume 18 of Aging-US on March 2, 2026, titled “D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice.” Led by Naidu B. Ommi from the Orentreich Foundation for the Advancement of Science – with corresponding author Sailendra N. Nichenametla from … Read more

Experimental therapy eliminates pancreatic precancerous cells in mice study

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A new preclinical study in mice shows that precancerous cells in the pancreas can be eliminated before they have the chance to become tumors. Using an experimental therapy to target microscopic precancerous lesions in the pancreas nearly doubled survival in mouse models of pancreatic ductal adenocarcinoma (PDAC) compared to the same treatment given after cancer … Read more

Middle-aged men most vulnerable to aging effects of new PFAS

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Per- and polyfluoroalkyl substances (PFAS) – ‘forever chemicals’ in common parlance – are a class of thousands of synthetic chemicals often used in non-stick coatings, water-resistant fabrics, fire-fighting foams, food packages, cleaning products, and plastics. They contain exceptionally strong molecular bonds, which makes them hard to break down. PFAS pollution is increasingly detectable in water, … Read more

How GLP-1 drugs affect the body beyond weight loss and glucose control

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Widely used weight-loss and diabetes drugs show clear benefits, but emerging evidence clarifies their side effects, rare risks, and what clinicians should monitor long term. A recent review article published in the Journal of Clinical Investigation summarized the adverse effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual incretin receptor agonists such as tirzepatide. Of … Read more

Thermodynamic insights into histamine H1 receptor ligand binding

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G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide range of physiological processes and are the targets of more than 30% of currently marketed drugs. The histamine H1 receptor (H1R) is one such GPCR subtype that … Read more

Tiny organism offers insight into neurological side effects of chemotherapy

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Chemotherapy remains one of the most powerful tools in the fight against cancer, yet it often comes with significant long-term side effects that can dramatically affect patients’ quality of life. Among the most debilitating is Chemotherapy-Induced Peripheral Neuropathy, which impacts both the central and peripheral nervous systems and affects up to 85% of cancer patients … Read more

Tumor-targeted chimeric drug increases efficacy and limits side effects

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Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors at higher doses, while reducing side effects in healthy tissue. An Aurora kinase A (AURKA) inhibitor is viewed as a lethal synthetic … Read more

Newly discovered survival pathway explains stubborn EGFR-driven lung cancers

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Scientists from A*STAR Institute of Molecular and Cell Biology (A*STAR IMCB) have identified why certain lung cancer cells become highly resistant to treatment after developing mutations in a key gene called EGFR (epidermal growth factor receptor). In a study published in Science Advances, the researchers revealed a previously unknown survival mechanism and demonstrated that disrupting … Read more