For decades, multiple sclerosis research has focused on myelin, the insulation around the brain’s wiring. Scientists paid less attention to another loss that was happening in parallel: neurons in the cortex, the seat of higher thinking and cognition, were quietly dying. A team led by UC San Francisco, University of Cambridge, and Cedars-Sinai Medical Center … Read more
A new editorial was published in Volume 18 of Aging-US on February 8, 2026, titled “Polyploidy-induced senescence: Linking development, differentiation, repair, and (possibly) cancer?” In this editorial, Iman M. Al-Naggar of the University of Connecticut School of Medicine, UConn Health, and the University of Connecticut Center on Aging, with George A. Kuchel of the University of Connecticut Center on Aging, examines the … Read more
Blood-based DNA repair and stress-response signals reveal a brief molecular window preceding Parkinson’s diagnosis. Study: Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson’s disease. Image credit: Chinnapong/Shutterstock.com In a recent study published in npj Parkinson’s Disease, researchers examined DNA repair and integrated stress response (ISR) genes in healthy individuals and those … Read more
New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic “on switches” in cancer cells, called super-enhancers, drive unusually intense gene activity. That high gear creates stress on the DNA and can cause dangerous breaks. Cancer cells can often repair this … Read more
A new way of thinking about Alzheimer’s disease has yielded a discovery that could be the key to stopping the cognitive decline seen in Alzheimer’s and other neurodegenerative diseases. University of Virginia School of Medicine scientists have been investigating the possibility that Alzheimer’s is caused, at least in part, by the immune system’s wayward attempts … Read more
Emerging evidence links regular sugary drink intake to impaired sperm quality and DNA damage. Find out why experts recommend reducing SSBs for reproductive health. Recommendations for reducing the impact of SSBs on sperm health. Research shows that regular consumption of sugar-sweetened beverages (SSB) is associated with adverse effects on male reproductive health, primarily through hormonal … Read more
A new review was published in Oncotarget, Volume 16, on March 13, 2025, titled “Signaling pathway dysregulation in breast cancer.” In this review article, Dinara Ryspayeva and colleagues from Brown University provide a detailed look at how breast cancer cells change the way they communicate and grow-helping tumors survive, spread, and resist treatment. The review … Read more
Researchers at the University of Pittsburgh have identified a novel trigger of a deadly form of ovarian cancer: a subset of progenitor cells that reside in fallopian tube supportive tissue, or stroma. The discovery of these high-risk cells, described in a new study published today in Cancer Discovery, a journal of the American Association for … Read more
Mutations in the BRCA1 gene that are either inherited (germline) or acquired (somatic) might not be key to the initiation of prostate cancer, as previously thought, suggests the first study of its kind, published online in the open access journal BMJ Oncology. If confirmed in further studies, the findings suggest that it may be time to … Read more
A new study reveals that even low-dose, chronic exposure to air pollution can trigger liver inflammation, fibrosis, and metabolic disruptions, increasing the risk of fatty liver disease and other hepatic disorders. Study: Mouse study demonstrates liver damage from low-level PM2.5 exposure. Image Credit: Shutterstock AI Generator / Shuttersotck.com A recent study published in the Journal of … Read more