Kinase

How could bisphenol A raise depression risk? Study identifies six key molecular targets

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Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may influence biological pathways tied to major depressive disorder. Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock A new study … Read more

Updated EULAR recommendations guide treatment decisions for rheumatoid arthritis

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First published in 2010, the EULAR recommendations for the management of RA, the most frequent inflammatory rheumatic disease, have been relied upon by healthcare professionals and organisations worldwide to offer an up-to-date and robust analysis of the effectiveness and practical use of available DMARDs – from conventional agents such as methotrexate to biologics and Janus … Read more

Combined CDK4/6 and EGFR inhibition improves pancreatic cancer therapy

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Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect strategy to counter KRAS-driven malignancy without direct KRAS targeting. Virtually all pancreatic ductal adenocarcinomas (PDACs) are initiated by activating mutations in the … Read more

Unmasking the hyper-active circuitry of early Alzheimer’s

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Neuroscientists at King’s College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer’s disease.  Published in Translational Psychiatry, the study also demonstrated that a cancer medication has the potential to reduce this hyperconnectivity.  The research, funded by Alzheimer’s Society and conducted in brain cells of rats, showed that low levels of the protein amyloid-beta could induce … Read more

How somatic mutations shape disease and reveal new drug targets

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Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets for future precision medicine. Somatic genomics uncovers the outcomes of evolutionary competitions within our tissues, which can drive disease, counter monogenic disease, or protect from common diseases  In a recent study published in the journal Cell, researchers reviewed … Read more

Can GLP-1 drugs slow neurodegeneration? New review finds promising signals but limited clinical proof

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Emerging evidence suggests widely used metabolic drugs could influence brain aging pathways, yet large clinical trials are still needed to confirm whether they truly alter the course of neurodegenerative disease. Study: The promise of GLP-1 receptor agonists for neurodegenerative diseases. Image Credit: Antonio Marca / Shutterstock In a recent review published in the Journal of Clinical … Read more

Tumor-targeted chimeric drug increases efficacy and limits side effects

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Wistar scientists have combined a promising cancer therapy with a molecule that targets tumors to treat cancer more effectively. The new approach could be a way to deliver treatment directly to tumors at higher doses, while reducing side effects in healthy tissue. An Aurora kinase A (AURKA) inhibitor is viewed as a lethal synthetic … Read more

Purdue researchers discover new therapeutic target for triple-negative breast cancer

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A Purdue University team led by Kyle Cottrell has discovered a new therapeutic target for triple-negative breast cancer. “Triple-negative breast cancer is a particularly deadly form of breast cancer that currently lacks targeted therapies,” said Cottrell, an assistant professor of biochemistry. Cottrell, biochemistry graduate student Addison Young and their co-authors describe the discovery in the journal RNA. The … Read more

Loss of metabolic control mechanisms promotes uncontrolled cancer cell proliferation

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  Researchers from the University of Seville have participated in research to identify the molecular details of the regulation of an enzyme essential for sugar metabolism and closely linked to cell proliferation and growth: pyruvate kinase. The results, the fruit of an extensive collaboration between the team led by Professor Irene Díaz Moreno of the … Read more

AI identifies promising CDK9 inhibitors for cancer treatment

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A new and important discovery comes from the field of oncological research thanks to the joint work of researchers from the Sbarro Institute in Philadelphia, the National Cancer Institute – Pascale Foundation, and the University of Pisa. The study has shown how the use of artificial intelligence (AI) can represent an extremely effective tool for … Read more