Proteome

Unmasking the hyper-active circuitry of early Alzheimer’s

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Neuroscientists at King’s College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer’s disease.  Published in Translational Psychiatry, the study also demonstrated that a cancer medication has the potential to reduce this hyperconnectivity.  The research, funded by Alzheimer’s Society and conducted in brain cells of rats, showed that low levels of the protein amyloid-beta could induce … Read more

Expanded Seq-Scope method boosts gene-mapping resolution within tissues

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In 2021, a technology developed at University of Michigan, called Seq-Scope, revolutionized the ability to map gene activity within intact tissue at microscopic resolution, enabling researchers to measure all expressed mRNA molecules and determine precisely where they are located within the tissue, using an Illumina sequencer machine. The team behind the Seq-Scope method, led by Jun … Read more

New Antibiotics Show Promise in Disrupting Tuberculosis Bacteria

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Archyde Tuberculosis (TB) remains one of the world’s most significant public health challenges, claiming an estimated 1.3 million lives in 2022 alone. The emergence of drug-resistant strains, particularly in regions like… You can read the full story here: New Antibiotics Show Promise in Disrupting Tuberculosis Bacteria. Source link

Experimental antibiotics disrupt bacterium that causes tuberculosis

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Researchers from the University of Sydney and the Centenary Institute have discovered how a promising class of experimental antibiotics disrupts the bacterium that causes tuberculosis (TB), paving the way for urgently needed new treatments. Globally, TB remains a major health crisis, claiming around 1.2 million lives each year and ranking among the world’s deadliest infectious … Read more

Multi-omics analysis uncovers molecular drivers of non-viral liver cancer development

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Researchers discover that inflammation and aging contribute to non-viral liver cancer development. Green tea’s role in reversing some of the pathway dysregulation that may contribute to the cancer development and other therapies explored.  Liver cancer can arise spontaneously from healthy liver tissue. Recently, however, researchers have discovered an increasing correlation between some liver cancers and … Read more

Proteomic mapping identifies biomarkers driving healthy aging and preventing chronic diseases

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A groundbreaking study reveals how blood proteins can predict disease risk, track health status, and offer new strategies to combat aging-related conditions. Study: Longitudinal serum proteome mapping reveals biomarkers for healthy ageing and related cardiometabolic diseases. Image Credit: ArtemisDiana / Shutterstock A recent study published in the journal Nature Metabolism identified biomarkers of healthy aging and cardiometabolic … Read more