A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target.
Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com
A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes.
What causes insulin resistance?
Diabetes is a chronic disease that occurs when the body cannot adequately produce or use insulin, a hormone that facilitates the transportation of glucose from the blood into cells for energy. The activation of insulin receptors, which are highly expressed on the luminal side of endothelial cells, induces…