Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect strategy to counter KRAS-driven malignancy without direct KRAS targeting. Virtually all pancreatic ductal adenocarcinomas (PDACs) are initiated by activating mutations in the … Read more
Researchers report that declining PPP2R5C levels in blood may signal early Alzheimer’s pathology, offering new insight into tau regulation and future diagnostic strategies Study: Neuronal PPP2R5C in plasma is a potential biomarker for early diagnosis of Alzheimer’s disease In a recent study published in the journal Cell Reports Medicine, researchers identified protein phosphatase 2 regulatory subunit … Read more
A clever natural experiment in Canada suggests a routine shingles vaccine may do more than prevent rash. Instead, the vaccine could help delay the onset of dementia in later life. Study: Herpes zoster vaccination and incident dementia in Canada: an analysis of natural experiments. Image credit: uganov Konstantin/Shutterstock.com A recent study in Lancet Neurology investigated … Read more
New evidence from Indian patients shows that severe COVID-19 is associated with distinct mitochondrial methylation signatures and altered mitochondrial proteins, pointing to disrupted energy metabolism as a key feature of critical illness. Study: SARS-CoV-2 altered mitochondrial DNA methylation in Indian COVID-19 patients. Image Credit: CI Photos / Shutterstock A recent study published in the journal Scientific … Read more
Consuming a high-fat diet can lead to a variety of health problems – not only weight gain but also an increased risk of diabetes and other chronic diseases. At the cellular level, hundreds of changes take place in response to a high-fat diet. MIT researchers have now mapped out some of those changes, with a … Read more
New research reveals how plant-based flavonoids can regulate gut hormones like GLP-1 and ghrelin, offering a natural strategy to manage insulin resistance and slow the progression of type 2 diabetes. Study: The Emerging Role of Flavonoids in the Treatment of Type 2 Diabetes Mellitus: Regulating the Enteroendocrine System. Image Credit: Shutterstock AI Generator / Shutterstock.com A … Read more
Endometriosis, a prevalent gynecological condition, is characterized by the growth of endometrial-like tissues outside the uterus, leading to severe pain and infertility in affected women. The pathogenesis of endometriosis remains elusive, and effective treatments are limited, highlighting the need for a deeper understanding of its molecular mechanisms. A pivotal role of P21-activated kinase 5 (PAK5) … Read more
A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more
Review explains how olive oil’s bioactive compounds influence key genetic pathways to improve glucose metabolism, reduce inflammation, and support beta-cell function—offering a natural approach to fighting Type 2 Diabetes. Review: Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus. Image Credit: sebra / Shutterstock In a recent review published in … Read more