A new research paper was published in Volume 18 of Aging-US on March 2, 2026, titled “D, L-Buthionine-(S, R)-sulfoximine recapitulates the anti-obesity effects of sulfur amino acid restriction without the associated deleterious effects on bone in male mice.” Led by Naidu B. Ommi from the Orentreich Foundation for the Advancement of Science – with corresponding author Sailendra N. Nichenametla from … Read more
Many people may have a dim view of their fat tissue, yet scientists have come to recognize adipose as a necessary and metabolically active organ, carrying out many vital functions within the body. In the case of obesity, too much fat can contribute to conditions such as diabetes and heart disease. Intriguingly, for people with … Read more
A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering potential therapeutic applications for osteoporosis. NELL2 promotes osteoblast differentiation and inhibits adipocyte formation in bone marrow stromal cells, addressing the bone remodeling imbalance in osteoporosis. The study further uncovers the molecular mechanism of NELL2’s action, revealing … Read more
A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study: Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more