Clinically available KRAS inhibitors mainly target G12C, which is rare in PDAC and often acquires resistance. Oncogenic KRAS inactivates RB1 via CDK4/6, while RB1 mutation is rare. Thus, CDK4/6 inhibition offers an indirect strategy to counter KRAS-driven malignancy without direct KRAS targeting. Virtually all pancreatic ductal adenocarcinomas (PDACs) are initiated by activating mutations in the … Read more
A novel approach to improving survival in treatment-resistant Cancers News-Medical Source link
A large genetic analysis suggests that one amino acid linked to protein metabolism could influence how long we live, with potential sex-specific effects that challenge assumptions about diet and longevity. Study: The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study. Image Credit: Oleg Troino / Shutterstock In a recent study … Read more
A new study has unveiled when chronic myeloid leukemia, a type of cancer that affects the blood and bone marrow, arises in life and how fast it grows. Researchers reveal explosive growth rates of cancerous cells years before diagnosis and variation in these rates of growth between patients. Such rapid growth rates had previously not … Read more
Hematopoietic and lymphocytic neoplasms (HLNs) are a diverse group of malignancies affecting blood and lymphatic systems, with outcomes varying from manageable conditions to fatal diseases. Traditional classifications rely on morphology, karyotyping, and fluorescence in situ hybridization (FISH). However, recent advancements in next-generation sequencing (NGS) allow simultaneous genetic profiling of multiple genes, enhancing diagnostic precision and … Read more
Insulin resistance precedes and predicts the onset of type 2 diabetes mellitus (DM2), a chronic disease that causes high morbidity and mortality worldwide. In affected people, insulin is unable to facilitate the uptake of glucose through tissues and organs, leading to an increase in blood glucose (chronic hyperglycemia). Since skeletal muscle is the tissue that … Read more
A new study uncovers how endothelial cells contribute to insulin resistance in obesity-associated diabetes, highlighting adrenomedullin as a potential therapeutic target. Study:Â Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Image Credit: Kateryna Kon / Shutterstock.com A recent study published in Science investigates the underlying mechanisms of endothelial insulin resistance involved in obesity-associated diabetes. What … Read more
Review explains how olive oil’s bioactive compounds influence key genetic pathways to improve glucose metabolism, reduce inflammation, and support beta-cell function—offering a natural approach to fighting Type 2 Diabetes. ​​​​​​​Review: Impact of Olive Oil Components on the Expression of Genes Related to Type 2 Diabetes Mellitus. ​​​​​​​Image Credit: sebra / Shutterstock In a recent review published in … Read more