Background and aims The rate of functional cure (HBsAg loss) remains unsatisfactory following pegylated interferon (PEG-IFN) treatment in chronic hepatitis B. To optimize PEG-IFN administration, this study aimed to evaluate virological markers to predict functional cure and/or hepatitis B e antigen (HBeAg) loss. Methods Relevant studies assessing virologic markers for predicting functional cure and HBeAg … Read more
The WHO recommends blood collection from voluntary, non-remunerated donors as crucial for ensuring a safe and sufficient blood supply. These donors exhibit a reduced risk of TTIs compared to commercial donors and family replacements. This study documented the prevalence of various TTIs in prospective blood donors at the FMC Azare. In our study, the prevalence … Read more
In this nationwide, population-based cohort of COVID-19 patients, we found an increased risk of severe COVID-19 (hospitalization, ICU treatment or death) in individuals with chronic HBV infection, even after adjusting for potential confounders. In addition to an increased risk in individuals who were male, elderly, non-vaccinated, and with low- socioeconomic status (SES), the multivariable models … Read more
With over 600 known human viruses and new ones emerging, experts highlight how climate change, globalization, and zoonotic spillover are accelerating viral threats—are we ready for the next pandemic? Invited Review: Human viruses: An ever-increasing list. Image Credit: Lightspring / Shutterstock In a recent review published in the journal Virology, researchers examined the increasing diversity of human … Read more
New recommendations address advances in immunosuppressive therapies and highlight antiviral prophylaxis for high-risk patients. Study: AGA Clinical Practice Guideline on the Prevention and Treatment of Hepatitis B Virus Reactivation in At-Risk Individuals. Image Credit: Josep Suria / Shutterstock.com In a recent study published in Gastroenterology, researchers update clinical practice guidelines for how to prevent and monitor … Read more
Background and aims The quantitative effects of alcohol consumption on cirrhosis and hepatocellular carcinoma (HCC) in hepatitis B virus (HBV) infection are unknown. This study aimed to establish a dose-dependent model of alcohol consumption on the risks of cirrhosis and HCC. Methods PubMed, Embase, the Cochrane Library, Web of Science, and four Chinese databases were … Read more
Schlaak JF. Current Therapy of Chronic Viral Hepatitis B, C and D. J Pers Med. 2023;13:964. Article PubMed PubMed Central Google Scholar Burén S, Gomes AL, Teijeiro A, Fawal M-A, Yilmaz M, Tummala KS, et al. Regulation of OGT by URI in Response to Glucose Confers c-MYC-Dependent Survival Mechanisms. Cancer Cell. 2016;30:290–307. Article CAS PubMed … Read more