Cartilage

Study sheds light on potential therapeutic strategies for post-traumatic osteoarthritis

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Post-traumatic osteoarthritis often affects younger, active individuals and progresses quickly following ligament or cartilage injury. Chondrocytes, the sole cell type in articular cartilage, survive in a low-oxygen environment by relying heavily on glycolysis, producing large amounts of lactate. While lactate has traditionally been associated with tissue stress and inflammation, emerging evidence suggests it also functions … Read more

Targeted PET/CT tracer improves early prediction of treatment response in rheumatoid arthritis patients

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A new targeted PET/CT tracer can detect treatment response in rheumatoid arthritis patients in as little as four weeks, and potentially even at the start of treatment, according to new research published in The Journal of Nuclear Medicine. Compared to the three to six months currently required to establish treatment efficacy, this new imaging technique could … Read more

Early bone molecular changes signal osteoarthritis progression

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Osteoarthritis often goes undetected until cartilage damage is advanced, limiting treatment options. A new study shows that molecular changes in subchondral bone occur earlier and can signal disease progression before cartilage loss. Using spatial mass spectrometry imaging and synovial fluid proteomics, researchers identified bone-derived protein signatures beneath intact cartilage that were also detectable in joint … Read more

Study identifies Apex1 as a redox-regulated driver of fracture repair

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Bone fractures usually heal efficiently, but in some patients this process fails, causing nonunion. A recent study identifies Apex1 as a redox-regulated driver of fracture repair. Using genetic mouse models, researchers show Apex1 controls early Bmp2 activation and later chondrocyte maturation, coordinating callus formation, vascularization, and cartilage-to-bone transition. These findings highlight oxidative stress regulation as … Read more

The Hoddle of Coffee: Tottenham Hotspur News and Links for Monday, June 2

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We’re at the beginning of a fresh month for Tottenham Hotspur, which means it’s time to look at the month ahead. There’s very little to point to this month. Because of the Club World Cup, we’ve got a strange transfer window this year. The window will first run from Sunday through June 10, and then … Read more

Breakthrough study finds genes behind calcium pyrophosphate deposition disease

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In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused by calcium pyrophosphate (CPP) crystal deposition in joints. The findings of this novel study in the Annals of the Rheumatic Diseases, … Read more

WPI researcher receives NSF CAREER Award to create bioadhesives for medical applications

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A Worcester Polytechnic Institute (WPI) researcher is developing a new class of medical adhesives by bringing together hydrogels and glue-like polymers to safely and reliably connect human tissues to therapeutic devices implanted in the body, such as pacemakers, insulin pumps, and artificial joints. Jiawei Yang, an assistant professor in the Department of Mechanical and Materials Engineering who is … Read more

Osteochondral Defect Repair: Queen Mary Breakthrough

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Novel Joint Repair Method Shows Promise in Preventing Osteoarthritis Table of Contents Novel Joint Repair Method Shows Promise in Preventing Osteoarthritis Agrin-Derived Polypeptide: A Catalyst for Cartilage Regeneration… The post Osteochondral Defect Repair: Queen Mary Breakthrough appeared first on NewsyList. Source link

Queen Mary scientists invent a new way to repair osteochondral defects

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Scientists at Queen Mary University of London have invented a new way to repair osteochondral defects – a common form of joint damage often caused by sports injuries or trauma – and to prevent progression to osteoarthritis.  The treatment uses Agrin, the protein which builds and maintains the link between our motor neurons and muscle … Read more

Single-cell analysis reveals key chondrocyte subpopulations in osteoarthritis

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Chondrocytes are specialized cells that are essential for cartilage maintenance and repair, and their dysfunction is central to the development of joint diseases like osteoarthritis (OA). However, the cell heterogeneity of chondrocytes in human articular cartilage is still not well defined, which hinders understanding of the pathogenesis of OA. This research, published in the Genes … Read more