Investigators at Mass General Brigham have uncovered how resistance to chemotherapies may occur in some cancers. Researchers focused on a pathway that harnesses reactive oxygen species (ROS) to kill cancer cells. The study found that mutations to VPS35, a key player in this pathway, can prevent chemotherapy-induced cell death. These results, published in Nature, could … Read more
Scientists uncover how the breakdown of a critical sugar-rich layer in brain blood vessels accelerates aging and disease—offering a new therapeutic target to restore brain health. Study: Glycocalyx dysregulation impairs blood–brain barrier in ageing and disease. Image Credit: ART-ur / Shutterstock A recent study published in the journal Nature showed that the dysregulation of the brain endothelial … Read more
Lung cancer is a particularly challenging form of cancer. It often strikes unexpectedly and aggressively with little warning, and it can shapeshift in unpredictable ways to evade treatment. While researchers have gleaned important insights into the basic biology of lung cancer, some of the disease’s molecular maneuvers have remained elusive. Now, a team led by … Read more
Mitochondrial defects are associated with the development of diseases such as type 2 diabetes (T2D). Studies in mice and in human tissues, by researchers at the University of Michigan, have now found that dysfunctional mitochondria trigger a response that affects the maturation and function of pancreatic β-cells. They found that in T2D dysfunctional mitochondrial quality … Read more