According to a study published in Nature by an international team led by the University of California, San Diego, childhood exposure to the bacterial toxin colibactin could drive early-onset colorectal cancer (CRC). The first author is Marcos Díaz-Gay, PhD, head of the new Digital Genomics Group at the Spanish National Cancer Research Center (CNIO) in Madrid, … Read more
In Latin America, efforts to implement preventive strategies, diagnostic tools, and personalized treatment for patients with rheumatic diseases often face significant barriers. However, there have been promising developments, many of which have been driven by the growing field of genomic medicine. One such initiative is the Ibero-American Research Consortium on the Genetics of Rheumatic Diseases … Read more
Genetic testing in patients with atrial fibrillation (AF) may identify those at higher risk of developing incident cardiomyopathy or heart failure, new research from the Netherlands suggested. In a study that included two longitudinal cohorts (the All of Us Research program and the UK Biobank), the prevalence of inherited rare gene variants associated with cardiomyopathy … Read more
Advanced Therapy Shows Promise for Difficult-to-Treat Leukemia Cases Table of Contents Advanced Therapy Shows Promise for Difficult-to-Treat Leukemia Cases The Evolution of Treatment for Ph+ ALL Extending Treatment Beyond Initial Induction: A New Analysis Impact on Long-Term Outcomes and Transplantation Safety Considerations and Future Directions Ponatinib Demonstrates Efficacy and Improved Safety Profile in Philadelphia Chromosome-Positive … Read more
More than 60% of patients with cervical cancer and 30% of those with endometrial cancer are diagnosed at an advanced stage, when survival rates are lowest. Although intensifying screening may seem logical, unnecessary procedures can be harmful. Routine procedures such as ultrasound, though often considered harmless, can lead to poorly indicated hysteroscopies and unnecessary biopsies, … Read more
Primary care physicians (PCPs) often face challenges in diagnosing complex pulmonary issues in patients, particularly when nonspecific symptoms appear similar to cardiovascular issues, asthma, or chronic obstructive pulmonary disease. However, clinicians can cover both pulmonary and cardiovascular concerns during an exam, potentially shortening delays in the diagnosis of interstitial lung diseases (ILDs), including pulmonary fibrosis … Read more
Researchers at the University of Nottingham have developed a new genetic test that can diagnose brain tumours in as little as 2 hours The test, called ROBIN, uses PromethION nanopore sequencing to deliver rapid methylome classification. The researchers said results could be available intraoperatively, allowing clinicians to make faster, more informed decisions. The same assay … Read more
This transcript has been edited for clarity. This is Dr JoAnn Manson, professor of medicine at Harvard Medical School and Brigham and Women’s Hospital. I’d like to talk with you about a recent report in the American Journal of Clinical Nutrition that suggests vitamin D supplementation has a promising role in protecting telomeres and slowing … Read more
The teratogenic risk of antiepileptic drugs (AEDs) has been a major concern in pharmacovigilance over the past several decades. However, neurodevelopmental and autism-related risks associated with these medications have gradually emerged. Although international registries provide information, they are not sufficiently comprehensive to fully assess the risks posed by many AEDs introduced in the past 20 … Read more
TOPLINE: In a multicenter cohort study of 575 South Korean patients with BRCA1 or BRCA2 pathogenic variants, breast-conserving treatment demonstrated comparable oncologic outcomes to mastectomy over a median follow-up of 8.3 years. After propensity score matching, no significant differences between the two surgical approaches were found in terms of locoregional recurrence, distant recurrence, and overall … Read more