TOPLINE: In patients with locally advanced rectal cancer who receive neoadjuvant therapy, radiation dose intensification improves pathologic complete response but leads to a small increase in acute toxicities. METHODOLOGY: Preoperative radiochemotherapy is standard of care for treating locally advanced rectal cancer, but 20%-30% of the patients develop metastatic disease. Although radiation dose escalation has been … Read more
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TOPLINE: Blood pressure (BP) measurements taken in a public space — with and without ambient noise — were minimally different from readings obtained in a private, quiet office. Mean systolic BP varied by less than 1 mm Hg between settings. Although guidelines advise measuring BP in a quiet place, public venues may be valid options … Read more
TOPLINE: Type I interferon (IFN) score may effectively predict disease progression in limited cutaneous systemic sclerosis (lcSSc), with patients having a high IFN activity presenting worse clinical outcomes. METHODOLOGY: Researchers conducted a longitudinal retrospective analysis to investigate whether the serum IFN score could predict clinically meaningful progression in patients with lcSSc using a novel composite … Read more
The Evolving Landscape of Cannabis and Cognition: What’s Next? Table of Contents The Evolving Landscape of Cannabis and Cognition: What’s Next? Unveiling the Brain’s Response to Cannabis Did You Know? Short-Term Effects and Long-Term Implications Pro Tip: Navigating the Complexities of Cannabis Use the Future of Cannabis Research FAQ Recent research has ignited a crucial … Read more
TOPLINE: Heavy lifetime cannabis use is linked to reduced brain activation during working memory tasks in young adults, while recent use is also associated with reduced activation during cognitive tasks, new research shows. METHODOLOGY: Researchers analyzed data collected between 2012 and 2015 from the Human Connectome Project. The cross-sectional study included more than 1000 young … Read more
TOPLINE: Time-restricted eating (TRE) doesn’t significantly reduce visceral adipose tissue (VAT) but leads to significant reductions in body weight compared with usual care in adults with overweight or obesity. METHODOLOGY: Although previous studies suggest that TRE may lead to modest weight loss and improvements in cardiometabolic health, the optimal timing of the eating window in … Read more
Archyde Empagliflozin and Weight Loss: A Promising First-Line Treatment for Diabetes and Prediabetes Table of Contents 1. Empagliflozin and Weight Loss: A Promising First-Line Treatment for Diabetes and Prediabetes 2. Understanding the Study 3. Key Findings 4. What This Means for patients 5. Limitations and Future Directions 6. Conclusion 7. How Does Empagliflozin Contribute to … Read more
Charity Scott, a 51-year-old trauma therapist in Los Angeles, entered menopause in May this year but has been dealing with hot flashes for about a decade. “I was working with kids as a teacher, and they’d come up to give me a hug and be like, ‘Ew, why are you all wet?’” she recalls. “The … Read more
For over 200 years, researchers have been captivated by axolotl salamanders (Ambystoma mexicanum) and their remarkable regenerative abilities, seeking to uncover secrets that could revolutionize regenerative medicine, including the scarless healing of wounds. “The axolotl salamander is the most studied animal ever in science for its neotenic ability to regenerate,” Jill S. Waibel, MD, dermatologist … Read more