Huntington’s disease is a devastating brain disorder that slowly robs people of movement, memory and personality. It is caused by a toxic protein that builds in brain cells and ultimately kills them. For years, scientists have known that this harmful protein doesn’t stay put – it spreads from one brain cell to another. However, exactly … Read more
New gene therapies such as AMT‑130 are beginning to slow Huntington’s disease progression, shifting the outlook from inevitable decline toward longer periods of preserved function and quality of life. prostooleh on freepik For generations, a diagnosis of Huntington’s disease has carried a heavy sense of inevitability, with families told that nothing could change the course … Read more
A team from the Faculty of Medicine and Health Sciences and the Institute of Neurosciences at the University of Barcelona (UBneuro) has applied advanced artificial intelligence techniques to better understand why Huntington’s disease can begin at very different ages in patients. This hereditary neurodegenerative condition, which causes motor, cognitive, and psychiatric impairments, is caused by … Read more
A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease? They found that HTT is something like a traffic controller inside neurons, moving different cargo along neuronal highways called axons in concert with other proteins key for cellular function … Read more
The cells with electrophysiological activity obtained at the University of the Basque Country (UPV/EHU) are opening up new avenues for the study of neurodegenerative diseases and the development of future autologous transplants. A UPV/EHU study published in the prestigious journal Stem Cell Research & Therapy has proven that stem cells extracted from human … Read more
Subtle signs of neurodegeneration can be detected in blood, cerebrospinal fluid (CSF), and through neuroimaging, up to two decades before motor symptoms in Huntington’s disease (HD) present, new research showed. Investigators believe these early biomarkers could pave the way for novel interventions that could improve outcomes for individuals at risk for HD. Sarah Tabrizi, PhD … Read more
People genetically susceptible to Huntington’s disease often see their movement, mood, and cognition decline slowly over time. The cause is related to expansion of repeating DNA units, in which specific strings of genetic code-in this case, a series of cytosine-adenine-guanine nucleotides, or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary … Read more
TOPLINE: Beta-blocker use is associated with a 34% reduction of onset in premanifest Huntington disease (preHD) and slower progression in early motor-manifest Huntington disease (mmHD), new research shows. METHODOLOGY: In this longitudinal multicenter study, 174 beta-blocker users with preHD (mean age, 46.4 years; 66% women) were matched with 174 nonusers (mean age, 48 years; 66% … Read more