Kidney failure

New marker identifies the functional maturity and heterogeneity of stem cell–derived islet organoids

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Over 500 million people worldwide suffer from diabetes-a disease that contributes to major complications such as stroke, kidney failure, cancer, and Alzheimer’s disease. At the heart of this condition lies the dysfunction of pancreatic islets, the mini-organs called organoids responsible for regulating blood sugar, in both autoimmune type 1 diabetes and stress-induced type 2 diabetes. … Read more

Necrosis: Key to Longevity & Space Health?

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Archyde: Latest World News, Economy, Entertainment, Health, Technology & Sports Updates Necrosis: Unlocking Secrets of Cell Death to Combat Aging and Disease London, United kingdom – Groundbreaking research illuminates how necrosis, a form of cell death, could revolutionize our approach to… You can read the full story here: Necrosis: Key to Longevity & Space Health?. … Read more

NICE Approves Sparsentan for Kidney Disease Treatment

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The National Institute for Health and Care Excellence has recommended sparsentan (Filspari, Vifor Pharma) for treating primary immunoglobulin A nephropathy in adults. The recommendation reverses NICE’s February decision to reject NHS funding for the drug. The regulator had previously said available evidence did not demonstrate value for money. The manufacturer provided additional analyses and agreed to … Read more

S3 Episode 5: Managing Type 2 Diabetes and CKD: SGLT2 Inhibitors vs GLP-1s

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This transcript has been edited for clarity. For more episodes, download the Medscape app or subscribe to the podcast on Apple Podcasts, Spotify, or your preferred podcast provider. Carol H. Wysham, MD: Hello. I’m Dr Carol Wysham. Welcome to season 3 of the Medscape InDiscussion Type 2 Diabetes podcast series. Today, we’ll discuss chronic kidney … Read more

Maternal Preeclampsia Tied to Kidney Disease Risk in Kids

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TOPLINE: Children exposed to maternal preeclampsia and born at term (37 weeks or more) were 26% more likely to develop kidney disease in the first year of life than those not exposed. They also faced notably high risks for chronic, unspecified, and diabetic kidney diseases as they grew older, particularly at or after 25 years … Read more

Pentoxifylline Ineffective in Alcoholic Hepatitis With AKI

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TOPLINE: Pentoxifylline, an anti–tumor necrosis factor alpha agent, did not improve survival outcomes in patients with severe alcohol-associated hepatitis complicated by acute kidney injury (AKI). METHODOLOGY: Severe alcohol-associated hepatitis is a life-threatening condition with corticosteroid treatment as the only therapy demonstrating short-term benefits, leading to the investigation of potential alternative therapies, such as pentoxifylline, particularly … Read more

Red blood cells drive blood vessel damage in diabetes by exporting toxic vesicles

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A new study uncovers how diabetic red blood cells release toxic packages that damage blood vessels, revealing a promising path for preventing serious complications. EVs derived from RBCs of patients with T2D are taken up by the endothelium and impair endothelium-dependent relaxation via an EV-mediated transfer of the prooxidant enzyme Arg1. Proteoglycan remodeling is a … Read more

Sotagliflozin: Lower A1c & Weight, Even with Kidney Issues

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Sotagliflozin Shows Promise for Diabetes Management,Despite FDA Hurdles New research presented at the American Association of clinical Endocrinology (AACE) Annual Meeting 2025 suggests that sotagliflozin (Inpefa) can lower A1C levels and reduce body weight in individuals wiht type 2 diabetes. However, the benefits appear to be less pronounced in patients with moderate-to-severe chronic kidney disease … Read more

Acute Kidney Injury Tied to Poor Outcomes in Hospitals

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TOPLINE: A substantial proportion of patients admitted to hospitals in Italy experienced acute kidney injury (AKI), which was associated with worsened in-hospital mortality outcomes, longer hospital stays, and more frequent admissions to intensive care units (ICUs). METHODOLOGY: Researchers conducted a retrospective observational study to examine the incidence of AKI in two Italian university hospitals from … Read more

GPs Lead the Way in Home-Based Albuminuria Screening

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TOPLINE: Systematic home-based screening for albuminuria in primary care identified previously undiagnosed risk for chronic kidney disease (CKD), with greater participation among individuals invited by general practitioners (GPs). Overall, 8.7% of GP-invited participants had confirmed increased albuminuria, with 40.6% of them being newly diagnosed. METHODOLOGY: Researchers conducted a cross-sectional screening study to evaluate the effectiveness … Read more