Metabolomics

Metabolic profiling of frailty, associations with type 2 diabetes and interaction with genetic susceptibility | Cardiovascular Diabetology

by

Study population Detailed information of the study design has been presented previously [15]. Briefly, the UK Biobank enrolled over 0.5 million participants aged 37 to 73 years from 22 sites across the UK between 2006 and 2010, and collected extensive information at recruitment, including data from touchscreen questionnaires, physical examinations, biological samples, and longitudinal follow-up for … Read more

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

by

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more

Metabolite profiles in spinal fluid predict mortality in tuberculous meningitis

by

Radboudumc researchers Kirsten van Abeelen, Edwin Ardiansyah, Sofiati Dian, Vinod Kumar, Reinout van Crevel and Arjan van Laarhoven used metabolomics to study cerebrospinal fluid (CSF) samples from tuberculous meningitis patients in Vietnam and Indonesia, with long-standing collaborators from Bandung and Jakarta (Indonesia), the Broad Institute (Boston) and the Oxford University Research Unit in Ho Chi … Read more

NIH researchers develop poly-metabolite score to measure ultra-processed food intake

by

For the first time, researchers at the National Institutes of Health (NIH) identified patterns of metabolites in blood and urine that can be used as an objective measure of an individual’s consumption of energy from ultra-processed foods. Metabolites are left after the body converts food into energy, a process known as metabolism. Scientists used these … Read more

Autism Symptoms Associated with Gut Microbial Tryptophan Metabolites

by

Microbiome dysbiosis—changes in the composition of gut microbes that alter the metabolites present—has long been implicated in playing a causative role in the pathophysiology of autism spectrum disorder (ASD). However, the changes in the gut microbial metabolites that are associated with ASD-specific brain alterations have remained unknown. Now, a new study suggests that gut microbiome … Read more

Duke-NUS and NUS Medicine launch first-ever joint center to drive metabolomics research

by

In a strategic move for medical research and innovation, Duke-NUS Medical School and the National University of Singapore Yong Loo Lin School of Medicine (NUS Medicine) have launched the Systems Metabolomics center (SysMeC), their first-ever joint research center. This groundbreaking initiative is set to drive cutting-edge metabolomics research, unlocking new ways to detect diseases earlier … Read more

Gut microbes and the body work together to regulate fat metabolism

by

Beneficial gut microbes and the body work together to fine-tune fat metabolism and cholesterol levels, according to a new preclinical study by investigators from Weill Cornell Medicine and the Boyce Thompson Institute at Cornell University’s Ithaca campus. The human body has co-evolved with the beneficial microbes that live in the gut (termed the microbiota), resulting … Read more

Breastfeeding after COVID-19 vaccination is safe, with minimal changes to milk composition

by

Cutting-edge research shows SARS-CoV-2 infection disrupts milk composition, but vaccines ensure safety for breastfeeding moms and their babies. Study: Associations between SARS-CoV-2 Infection or COVID-19 Vaccination and Human Milk Composition: A Multi-Omics Approach. Image Credit: TORWAISTUDIO / Shutterstock In a recent study published in The Journal of Nutrition, a group of researchers investigated whether severe acute respiratory … Read more