Improved Treatment for Low-Grade PC Lesions

Archyde Expert Groups Advocate for Refined Approach to Diagnosing Indolent prostate Cancer May 8, 2025 Two leading international pathology societies are urging a shift in how indolent prostate cancers are detected and diagnosed, aiming to reduce overtreatment and improve patient outcomes. Teh Genitourinary Pathology Society (GUPS) and the International Society of Urological Pathology (ISUP) recently … Read more

Canadian Pediatricians Ill Prepared to Treat Drug Overdoses

Illicit drug toxicity is an “escalating public health emergency” in Canada that significantly affects adolescents, yet pediatricians are ill prepared to manage it, new research suggested. A study of more than 1000 pediatricians in Canada who care for young people aged 12-18 years found that while close to 14% reported caring for at least one … Read more

LC-HR-MS/MS Library of Drugs, Poisons and Their Metabolites database

Wiley, one of the world’s largest publishers and a global leader in research and learning, today announced the much-anticipated release of the second edition of Maurer, Meyer, Helfer, Weber: LC-HR-MS/MS Library of Drugs, Poisons, and Their Metabolites. Developed by renowned toxicologist Hans H. Maurer and his team, this database is a vital resource for LC-MS identification … Read more

Radiotherapy for Prostate Cancer: What Approach Works Best?

TOPLINE: Moderately hypofractionated radiotherapy, both isodose and dose-escalated, led to progression-free survival outcomes similar to that achieved with conventionally fractionated radiotherapy in patients with prostate cancer, but the dose-escalated regimen came with an increased risk for toxicities compared with the conventional approach, according to findings from a recent meta-analysis. METHODOLOGY: Moderately hypofractionated radiotherapy is now … Read more

‘Paracetamol Challenge’ Risks Fatal Consequences for Teens

The French National Agency for the Safety of Medicines and Health Products has alerted healthcare professionals and parents about a concerning trend known as the “Paracetamol Challenge” that is gaining popularity, particularly on social media, among children and adolescents. This challenge involves the deliberate ingestion of toxic doses of paracetamol to evaluate one’s resistance and … Read more

Adjuvant Chemo vs Radiotherapy Alone in Cervical Cancer

New findings on radiation plus adjuvant chemotherapy in patients with intermediate-risk cervical cancer seem to spell the end for the dual therapy in this group.  Results from a phase 3 clinical trial of 316 women who’d had radical hysterectomies found that adjuvant chemotherapy as treatment for their early-stage, intermediate-risk cervical carcinoma did not improve outcomes … Read more

Untangling Race-based Disparities in Endometrial Cancer

Tiffany White Tiffany White was 27 years old when she was diagnosed with endometrial cancer. White, a Chicago resident who works as a mental health counselor and an accounting director for a national nonprofit organization, presented to her gynecologist with tiredness, pain, and bleeding between periods. An ultrasound revealed the presence of polyps. After a … Read more

Breakthrough drug combination targets KRAS mutation in lung cancer

A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib-an FDA-approved drug in the market-and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer. The study, … Read more

SJS/TEN Survivors Show Lasting Cardiovascular Mortality Risk

TOPLINE: A study showed that survivors of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) had an increased risk for cardiovascular morbidity and mortality, which peaked within the first year and remained elevated for up to 7 years after the initial SJS/TEN diagnosis. METHODOLOGY: A retrospective study evaluated survivors of SJS/TEN from Taiwan’s National Health … Read more

Antidepressants in Pregnancy: Sudden Withdrawal Is Risky

Depression poses serious health concerns, particularly during pregnancy and after childbirth. Recent data from the United States are alarming, showing that nearly half of women stop taking antidepressants during pregnancy. A study published in JAMA Network Open highlights this trend, which may have serious consequences for both mothers and their children. The study, led by … Read more