A new research paper was published in Oncotarget, Volume 16, on March 21, 2025, titled “NSD2-epigenomic reprogramming and maintenance of plasma cell phenotype in t(4;14) myeloma.” Researchers Andrea Gunnell, Scott T. Kimber, Richard Houlston, and Martin Kaiser from The Institute of Cancer Research, London, studied how a gene called NSD2 affects the behavior of multiple myeloma (MM) cells. … Read more
An AI model trained on large amounts of genetic data can predict whether bacteria will become antibiotic-resistant. The new study shows that antibiotic resistance is more easily transmitted between genetically similar bacteria and mainly occurs in wastewater treatment plants and inside the human body. By understanding how resistance in bacteria arises, we can better … Read more
A pan-Canadian team has developed a new way to quickly find personalized treatments for young cancer patients, by growing their tumors in chicken eggs and analyzing their proteins. The team, led by researchers from the University of British Columbia and BC Children’s Hospital Research Institute, is the first in Canada to combine these two techniques … Read more
Swedish researchers have identified genetic variants that increase the risk of atherosclerosis. The aim is for these new findings to enable earlier detection of atherosclerosis and improved treatment of cardiovascular diseases such as heart attack and stroke. The study, published in the journal Nature Communications, represents the largest gene mapping of atherosclerosis using advanced diagnostic … Read more
A new study from Queen Mary University of London found that 9% of all reported adverse drug reactions (ADRs) reported to the UK medicines regulator are associated with medications where side effect risk is partly dependent on patient’s genes. Of this subset of ADRs, 75% were associated with only three genes that impact how the … Read more
Schizophrenia affects millions worldwide, yet its causes remain one of the greatest medical mysteries. In an exclusive Genomic Press Interview, Dr. Consuelo Walss-Bass, a pioneering researcher in psychiatric genetics, shares how both genetic predisposition and environmental factors contribute to severe mental health disorders. As the John S. Dunn Foundation Distinguished Chair in Psychiatry at UTHealth … Read more
The sugar glucose, which is the main source of energy in almost every living cell, has been revealed in a Stanford Medicine study to also be a master regulator of tissue differentiation – the process by which stem cells give rise to specialized cells that make up all the body’s tissues. It does so not … Read more
Background and aims Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms of TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore the specific molecular mechanisms through which TMAO promotes gallstone formation. Methods Enzyme-linked immunosorbent assays were used … Read more
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Scientists at deCODE genetics, a subsidiary of Amgen, reveal today in Nature Genetics associations between bipolar disorder and rare loss-of-function variants in two genes. Bipolar disorder is characterized by extreme mood swings, bouts of mania or hypomania, and episodes of depression. It is a highly heritable and serious condition, that when untreated comes with a … Read more