Researchers have discovered that mutations in the FOXJ3 gene act as a “master switch” failure, disrupting how the brain builds its layers and leading to FCD, a primary cause of drug-resistant epilepsy. The study reveals how FOXJ3 controls the formation of brain cortical layers during brain development by regulating the PTEN–mTOR signaling pathway. The PTEN-mTOR … Read more
Scientists reveal how evolution within our own tissues can drive disease, protect cells, and uncover hidden therapeutic targets for future precision medicine. Somatic genomics uncovers the outcomes of evolutionary competitions within our tissues, which can drive disease, counter monogenic disease, or protect from common diseases In a recent study published in the journal Cell, researchers reviewed … Read more
Inherited hyperbilirubinemia, encompassing Gilbert syndrome, Crigler-Najjar syndrome, Dubin-Johnson syndrome, and Rotor syndrome, represents a spectrum of disorders rooted in genetic defects affecting bilirubin metabolism and transport. The recent 2025 Expert Consensus provides a crucial framework for standardizing the diagnosis and management of these conditions. A key strength of the consensus is its clear stratification of … Read more
Atherosclerosis underlies most heart attacks and strokes and is now recognized as a chronic inflammatory disease rather than a simple disorder of cholesterol deposition. While immune cells such as macrophages have been widely studied, emerging evidence shows that vascular smooth muscle cells also play a central role in plaque development. These cells exhibit remarkable plasticity, … Read more
Background and objectives Oral microbiota dysbiosis and altered salivary cortisol levels have been linked to depression and anxiety. Given that bacterial transmission can occur between spouses, this study aimed to investigate whether the transmission of oral microbiota between newlywed couples mediates symptoms of depression and anxiety. Methods Validated Persian versions of the Pittsburgh Sleep Quality … Read more
A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 7, 2025, titled “Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet.” In this study, the research team, led by first author Naidu B. Ommi and corresponding author Sailendra N. Nichenametla from the Orentreich Foundation for the Advancement … Read more
A new research paper was published in Aging (Aging-US) Volume 17, Issue 4, on April 7, 2025, titled “Pharmacological recapitulation of the lean phenotype induced by the lifespan-extending sulfur amino acid-restricted diet.” In this study, the research team, led by first author Naidu B. Ommi and corresponding author Sailendra N. Nichenametla from the Orentreich Foundation for the Advancement … Read more
Archyde Impaired Synaptic Pruning in Autism: Immune Cell Dysfunction Identified Table of Contents 1. Impaired Synaptic Pruning in Autism: Immune Cell Dysfunction Identified 2. The Role of synaptic Pruning in Brain Growth 3. Macrophages and Synaptic Clearance: A New Clue 4. CD209 Gene: A Potential Mediator 5. Implications for Future Therapies 6. Source: 7. Frequently … Read more
Autism spectrum disorder (ASD) is a complex neurodevelopmental condition in which affected individuals experience difficulties in social communication and exhibit restricted, repetitive patterns of behavior or interests. A growing body of research suggests that neurobiological changes, particularly abnormalities in dendritic spines, tiny protrusions on nerve cells where synapses form, may be a hallmark of ASD. … Read more
Despite heightened obstetric risks, pregnant women may face a lower chance of developing Long COVID—findings that challenge assumptions and call for deeper insight into the immune landscape of pregnancy. Study: Long COVID after SARS-CoV-2 during pregnancy in the United States. Image Credit: Natalia Deriabina / Shutterstock In a recent study published in the journal Nature Communications, researchers … Read more