In aggressive lymphomas, inflammatory messengers reprogram the “conductors” of the immune system, causing lymph nodes structure to collapse. A team led by Simon Haas describes in “Nature Cancer” this process for the first time using single-cell and spatial analyses. Lymph nodes are highly organized command centers of the immune system. Within these structures, immune cells … Read more
Metastasis, the spread of cancer from a primary tumor to other parts of the body, is difficult to study in the lab, in part because researchers lack reliable ways to recreate the conditions cancer cells encounter as they travel through the bloodstream. Rice University bioengineers report a new platform designed to streamline one of the … Read more
Researchers from China have identified a novel bacteriophage that offers a highly promising “green” biocontrol solution against foodborne Salmonella. The study was published in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. This study was conducted to address the severe challenges posed by antimicrobial-resistant Salmonella to global food safety and public … Read more
One of oncology’s biggest challenges is that the same treatment can work well for some patients but fail completely in others. A study published in Nature Communications, from a multi-disciplinary team led by Dr Louise Fets at the LMS, has mapped the distribution of a type of targeted treatments, known as PARP inhibitors, using advanced imaging techniques and patient ovarian tumour samples. The research reveals that build up of these drugs in lysosomes – small compartments inside cells that normally act as “recycling centres” – can trap and … Read more
A research team led by Albert Einstein College of Medicine scientists has developed a new strategy to engineer immune cells that dramatically prolongs their effectiveness after being infused into patients to fight cancer and HIV, addressing a major limitation of current treatments. Their findings, published today in Science Advances, describe a manufacturing approach that, compared … Read more
Lipid nanoparticles, or LNPs, best known as the delivery vehicle for the COVID-19 mRNA vaccines received by billions of people, are now at the center of a much larger medical revolution. Researchers are racing to use them to ferry therapeutic mRNA into cells for cancer therapies and treatments for inflammatory diseases, as well as delivering … Read more
Researchers at the University of Gothenburg have identified a protein linked to an increased risk of metastasis and recurrence in lung cancer. The findings are presented in a study that paves the way for new precision medicine approaches, particularly for older patients. Lung cancer primarily affects older individuals. Despite this, many laboratory studies rely on … Read more
Published in The Lancet Neurology, a new review from the University of Colorado Anschutz in collaboration with UT Southwestern Medical Center, offers the latest scientific explanations for why ketogenic diets reduce seizures in people with epilepsy. The paper brings together insights from both laboratory discoveries and real‑world patient outcomes, showing that ketogenic diets do far more … Read more
A new study led by Pierre Close’s team (GIGA, Laboratory of Cancer Signaling, and WELRI Investigator) reveals how subtly disrupting the way tumors produce their proteins can trigger a potent antitumor immune response. Researchers from the University of Liège and international collaborators have discovered an unexpected way to to stimulate the immune system against cancer: … Read more
Sildenafil – an active ingredient also marketed under the name of Viagra – improves symptoms in patients with Leigh syndrome. This has now been reported in the Cell journal by researchers at Charité – Universitätsmedizin Berlin, together with teams from Heinrich Heine University Düsseldorf (HHU), University Hospital Düsseldorf (UKD), and the Fraunhofer Institute for Translational Medicine … Read more