Mono infection associated with threefold higher multiple sclerosis risk

Having the disease infectious mononucleosis, often called mono, caused by the Epstein-Barr virus is associated with an increased risk of developing multiple sclerosis (MS), according to a study published on April 1, 2026, in Neurology® Open Access, an official journal of the American Academy of Neurology. The Epstein-Barr virus is a herpes virus that is … Read more

DNA damage in gray matter neurons linked to MS progression

For decades, multiple sclerosis research has focused on myelin, the insulation around the brain’s wiring. Scientists paid less attention to another loss that was happening in parallel: neurons in the cortex, the seat of higher thinking and cognition, were quietly dying. A team led by UC San Francisco, University of Cambridge, and Cedars-Sinai Medical Center … Read more

A new global collaboration to expand patient-derived stem cell models and accelerate treatments

A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery – current cell models used for testing treatments do not currently reflect the diverse nature of the disease – that affects both researchers developing therapies and the people urgently waiting for them. The ALS Therapy Development Institute (ALS TDI), … Read more

Gut immune responses found to trigger brain inflammation in MS

Multiple sclerosis (MS) is a debilitating neurological disorder caused by malfunctioning immune responses that target the brain and spinal cord of the central nervous system (CNS). What makes our body turn against itself? Failure of the immune system to distinguish ‘self’ from ‘non-self’ entities leads to excessive autoimmune responses against self-proteins like myelin, which forms … Read more

Multiple sclerosis prevalence in England doubles due to better diagnosis

Multiple sclerosis (MS) has more than doubled in recorded prevalence in England from 2000 to 2020, increasing by 6% per year, largely due to improved diagnosis and longer life expectancy, finds a new study by University College London (UCL) and Imperial College London researchers. The team found that survival of people with MS improved significantly … Read more

Gene mutation that aids high-altitude survival could repair myelin sheath damage

A genetic mutation that helps animals like yaks and Tibetan antelopes survive at high altitudes may hold the key to repairing nerve damage in conditions such as cerebral paralysis and multiple sclerosis (MS). The finding, publishing March 13 in the Cell Press journal Neuron, reveals a naturally existing pathway that promotes regeneration after nerve damage and could open new doors for treating diseases like MS by leveraging molecules that are already present in the human body.  … Read more

New study identifies specific brain cells most vulnerable to ALS and dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments. There are currently no effective treatments. Many patients have a common hallmark: A protein called TDP-43 clumps together in the neurons of the brain to form tiny … Read more

Identifying common genetic markers for multiple sclerosis

A new study published in Neurology and led by Queen Mary University of London has revealed that people of South Asian, African , and European ancestry share many of the same genetic risk factors for multiple sclerosis (MS).  This new study is one of the most ancestrally diverse genetic analyses of MS conducted in the UK. MS affects around 150,000 people in the UK and more than two million people … Read more

Morning chronotype and exercise associated with reduced ALS risk

Being an early bird, also called a morning person, and being more physically active are associated with lower risks of amyotrophic lateral sclerosis (ALS), according to a preliminary study released February 25, 2026, that will be presented at the American Academy of Neurology’s 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online. … Read more

New technology maps protein production across individual brain cells

The brain’s ability to carry out everything from forming memories to coordinating movement depends on its cells producing the right proteins at the right time. But directly measuring this protein production, known as translation, across different types of brain cells has been a challenge. Now, scientists at Scripps Research and UC San Diego have developed … Read more