Endocrine

How could bisphenol A raise depression risk? Study identifies six key molecular targets

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Researchers combined genetic epidemiology, transcriptomics, molecular docking, and mouse experiments to show how a common endocrine-disrupting chemical may influence biological pathways tied to major depressive disorder. Study: Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation. Image Credit: monticello / Shutterstock A new study … Read more

Early-life PFAS exposure may hinder adolescent bone development

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Early-life exposure to per- and polyfluoroalkyl substances (PFAS) may influence how children’s bones develop during adolescence, according to new research published in the Journal of the Endocrine Society. PFAS are synthetic chemicals found in water, food and everyday products. These “forever chemicals,” many of which persist in the environment and in the human body, may interfere with normal development, including bone growth. “Adolescence is a key period for … Read more

Father’s nicotine use may increase diabetes risk for offspring

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A mouse study found that a father’s nicotine exposure can affect the offspring’s ability to process sugar and may contribute to diabetes risk, according to new research published in the Journal of the Endocrine Society. An estimated 40.1 million people in the United States have diabetes, according to the U.S. Centers for Disease Control and Prevention. Having diabetes … Read more

Researchers identify mechanism explaining chemical disruption of sex hormones

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Researchers at the University of Oulu have identified a previously unknown mechanism in humans that may explain why certain medicines and environmental chemicals disrupt the balance of sex hormones. The finding deepens scientific understanding of so‑called endocrine disruptors – chemicals known to interfere with the body’s hormonal systems. At the centre of the discovery is … Read more

Hormonal imbalance and gut microbes linked to cognitive deficits in patients with PitNETs

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Pituitary neuroendocrine tumors (PitNETs) are commonly associated with visual disturbances and endocrine abnormalities; however, many patients also experience cognitive deficits, particularly in memory, attention, and executive function, which significantly affect quality of life. Despite increasing recognition of this burden, the mechanisms underlying cognitive impairment remain unclear. Traditionally, cognitive changes have been attributed to tumor mass … Read more

Modern farming waste carries emerging contaminants that threaten ecosystems and health

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A new scientific review highlights a growing environmental challenge linked to modern food production. Researchers report that waste from livestock and aquaculture operations now contains a complex mix of emerging contaminants that can spread through ecosystems and ultimately affect human health. The study synthesizes recent global research on so-called new contaminants, including antibiotic residues, antibiotic … Read more

Palbociclib Improves Progression‑Free Survival in Double‑Positive Metastatic Breast Cancer: Results from the PATINA Phase 3 Trial

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Archyde “`html Palbociclib Extends Progression-Free Survival in Aggressive Breast Cancer, Landmark Study Reveals Table of Contents 1. Palbociclib Extends Progression-Free Survival in Aggressive Breast Cancer, Landmark Study Reveals 2. Understanding the… You can read the full story here: Palbociclib Improves Progression‑Free Survival in Double‑Positive Metastatic Breast Cancer: Results from the PATINA Phase 3 Trial. Source link

Palbociclib improves progression-free survival in HER2 positive breast cancer

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PrECOG, LLC, today announced the publication of final results from the pivotal phase 3 PATINA study in the New England Journal of Medicine (NEJM). The study evaluated whether adding palbociclib to anti-HER2 and endocrine therapy, following induction chemotherapy, could delay disease progression in patients with hormone receptor–positive (HR+), human epidermal growth factor receptor 2–positive (HER2+) metastatic … Read more

PFAS exposure increases gestational diabetes risk

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A comprehensive review of nearly 130 studies shows the strongest evidence to date that “forever chemicals” are associated with gestational diabetes, while underscoring uncertainty around other diabetes outcomes and the need for more prospective research. Study: Associations of perfluoroalkyl and polyfluoroalkyl substances with markers of glycaemic control, insulin secretion and sensitivity, and diabetes risk: a … Read more

Antibiotic use in infancy raises early puberty risk in girls, study finds

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Girls given antibiotics as newborns are more likely to hit puberty early, especially with multiple types of antibiotics. This large-scale study raises red flags about overuse of antibiotics in infancy and its long-term effects on hormonal development. Image Credit: New Africa / Shutterstock Girls given antibiotics during their first year of life, especially in the first three … Read more