Liver Transplantation

Vascularized liver tissueoid-on-a-chip recreates tissue regeneration and transplant rejection

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Dr. Vadim Jucaud’s lab at the Terasaki Institute has developed a vascularized liver tissueoid-on-a-chip (LToC) platform that recapitulates key structural, functional, and immunological features of human liver tissue, enabling the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system. Liver transplantation remains the primary therapeutic option for patients with end-stage … Read more

Spain Nears Legal Shift on HIV-Positive Donors

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Historically, the presence of HIV infection in a patient with end-stage organ failure has been considered an absolute contraindication for organ transplantation. However, advances in antiretroviral therapy have significantly improved life expectancy for people living with HIV to the extent that the condition is now generally managed as a chronic disease. At the same time, … Read more

‘Paracetamol Challenge’ Risks Fatal Consequences for Teens

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The French National Agency for the Safety of Medicines and Health Products has alerted healthcare professionals and parents about a concerning trend known as the “Paracetamol Challenge” that is gaining popularity, particularly on social media, among children and adolescents. This challenge involves the deliberate ingestion of toxic doses of paracetamol to evaluate one’s resistance and … Read more

Antihistamine shows promise for treating rare genetic liver disease

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A common antihistamine may offer hope for patients with a rare genetic disease that can lead to severe liver damage and ultimately require transplantation, according to new research from Rutgers Health. The study in Cellular and Molecular Gastroenterology and Hepatology found that chlorcyclizine, a decades-old allergy medication, could potentially treat erythropoietic protoporphyria (EPP), a condition … Read more