Myocardial Infarction

Impact of sodium–glucose transport protein-2 (SGLT2) inhibitors on the inflammasome pathway in acute myocardial infarction in type 2 diabetes mellitus: a comprehensive review | Cardiovascular Diabetology

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Yang L, Zhang X, Wang Q. Effects and mechanisms of SGLT2 inhibitors on the NLRP3 inflammasome, with a focus on atherosclerosis. Front Endocrinol (Lausanne). 2022;13:992937. PubMed  Google Scholar  Kim SR, Lee SG, Kim SH, Kim JH, Choi E, Cho W, et al. SGLT2 inhibition modulates NLRP3 inflammasome activity via ketones and insulin in diabetes with … Read more

Guideline-directed medical therapy boosts survival in the oldest heart attack patients

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Researchers have found that prescribing guideline-directed medical treatment (GDMT), regardless of the number of medications, can improve survival rates in patients 90 years of age and older following their first heart attack, with the greatest benefit observed in patients who received all four recommended post-acute myocardial infarction (AMI) therapies. These include beta-blockers, antiplatelets, lipid-lowering drugs, … Read more

Red blood cells drive blood vessel damage in diabetes by exporting toxic vesicles

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A new study uncovers how diabetic red blood cells release toxic packages that damage blood vessels, revealing a promising path for preventing serious complications. EVs derived from RBCs of patients with T2D are taken up by the endothelium and impair endothelium-dependent relaxation via an EV-mediated transfer of the prooxidant enzyme Arg1. Proteoglycan remodeling is a … Read more

Early combination treatment can prevent heart attacks and save lives

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Patients who receive an add-on medication soon after a heart attack have a significantly better prognosis than those who receive it later, or not all. This is according to a new study from researchers at Lund University in Sweden and Imperial College London. The findings suggest that treating patients earlier with a combination of statins … Read more

Low vitamin D levels damage erectile health via superoxide surge, study finds

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Low vitamin D doesn’t just weaken bones; it can sabotage sexual health, disrupt key biological defenses, and make common ED treatments less effective, according to new research. Study: Vitamin D deficiency induces erectile dysfunction: Role of superoxide and Slpi. Image Credit: Lightspring / Shutterstock In a recent study published in the British Journal of Pharmacology, researchers found … Read more

Immune gene expression changes in myocardial infarction revealed through bioinformatics

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Announcing a new article publication for Cardiovascular Innovations and Applications journal. This study was aimed at exploring immune-related genes and their expression changes in myocardial infarction (MI) through comprehensive bioinformatics methods and validating these genes as potential diagnostic and therapeutic targets. Gene expression data were analyzed from three datasets: GSE29111 and GSE66360, which were combined … Read more

COVID-19 speeds up artery plaque growth, raising heart disease risk

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New research reveals that even mild COVID-19 can silently worsen heart health, accelerating plaque buildup and inflammation—raising the risk of future heart attacks and strokes. Study: SARS-CoV-2 Infection Association with Atherosclerotic Plaque Progression at Coronary CT Angiography and Adverse Cardiovascular Events. Image Credit: Rocos / Shutterstock In a recent study published in the journal Radiology, a research … Read more