New mouse model sheds light on smell loss and neural regeneration

A new study suggests that stem cells thought to be dormant may offer clues to why our sense of smell declines or is lost. Using a newly devised, three-dimensional model to study the regeneration of nerve tissue in the nose, researchers at Tufts University School of Medicine and the Graduate School of Biomedical Sciences (GSBS) and colleagues have discovered … Read more

Ghrelin receptor identified as key to easing constipation in Parkinson’s patients

Considered the natural “hunger hormone”, Ghrelin could be the key to preventing debilitating chronic constipation experienced by people living with Parkinson’s disease, University of Queensland researchers have found. Associate Professor Sebastian Furness from the UQ School of Biomedical Sciences said the team discovered the body’s receptor for Ghrelin had a critical role in the normal … Read more

Study reveals dual role of TEAD proteins in neural development

Scientists at St. Jude Children’s Research Hospital found that, in neural development, the same set of proteins involved in cellular self-renewal can also facilitate differentiation with the right binding partner. The fundamental processes that govern neural development are complex and, as findings by scientists at St. Jude Children’s Research Hospital demonstrate, the underlying driving forces can even … Read more

Discovery reveals how neuronal ion channels store molecular memory

Researchers have discovered how an ion channel in the brain’s neurons has a kind of ‘molecular memory’, which contributes to the formation and preservation of lifelong memories. The researchers have identified a specific part of the ion channel at which new drugs for certain genetic diseases could be targeted. The study, led from Linköping University … Read more

New fruit fly study shows the whole-body impact of Alzheimer’s disease

While Alzheimer’s disease is mostly considered a disorder of the brain, emerging evidence suggests that the condition also affects other organs of the body. Working with the laboratory fruit fly, researchers at Baylor College of Medicine, the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital (Duncan NRI) and collaborating institutions provide a … Read more

Peptide nanostructures block amyloid buildup and boost neuron survival in lab tests

Scientists unveil a novel supramolecular therapy that shields human neurons from amyloid-induced damage, offering new hope for treating Alzheimer’s and related neurodegenerative diseases. Study: Supramolecular Copolymerization of Glycopeptide Amphiphiles and Amyloid Peptides Improves Neuron Survival. Image Credit: Shutterstock AI Generator / Shutterstock.com  A recent study published in the Journal of the American Chemical Society investigates the … Read more

Astrocytes found to drive brain rewiring during attention states

Researchers at Washington University School of Medicine in St. Louis have upended decades-old dogma of how connections between brain cells are rearranged during states of heightened vigilance or attention. The team found that a brain chemical associated with alertness, attention and learning alters brain connectivity and function not by acting directly on neurons, the cells … Read more

AI identifies brain cell types through electrical signatures

A decades-old challenge in neuroscience has been solved by harnessing artificial intelligence (AI) to identify the electrical signatures of different types of brain cells for the first time, as part of a study in mice led by researchers from UCL. Brains are made up of many different types of neurons (nerve cells in the brain), … Read more

New micropipette allows precise ion delivery to individual brain cells

Researchers at Linköping University have developed a new type of pipette that can deliver ions to individual neurons without affecting the sensitive extracellular milieu. Controlling the concentration of different ions can provide important insights into how individual braincells are affected, and how cells work together. The pipette could also be used for treatments. Their study … Read more

Study reveals opposing roles of two proteins in Huntington’s disease

A decade ago, University at Buffalo researchers shed some light on an enduring neuroscience mystery: How exactly does a mutated huntingtin protein (HTT) cause Huntington’s disease? They found that HTT is something like a traffic controller inside neurons, moving different cargo along neuronal highways called axons in concert with other proteins key for cellular function … Read more