Patients who stop GLP-1 drugs often restart or try alternatives

A large real-world study shows that patients who stop popular GLP-1–based weight-loss drugs often return to treatment or try alternative therapies, helping explain why average weight regain after discontinuation may be smaller than expected. Study: Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide. Image credit: KaterynaBorodina/Shutterstock.com Obesity treatment has … Read more

How are GLP-1 drugs reshaping treatment for obesity, diabetes, and heart disease?

A sweeping Lancet review reveals how modern incretin-based drugs are reshaping treatment for obesity and diabetes, delivering powerful weight loss while simultaneously protecting the heart, kidneys, and metabolic health. Review: GLP-1 receptor agonists and next-generation incretin-based medications: metabolic, cardiovascular, and renal benefits. Image Credit: Gecko Studio / Shutterstock In a recent review published in The … Read more

Tirzepatide shows dual benefits in sleep apnea trial improving metabolism and reducing inflammation

New clinical trial evidence suggests targeting both obesity and sleep-disordered breathing together may reshape cardiometabolic risk management in obstructive sleep apnea. Tirzepatide on obstructive sleep apnea-related cardiometabolic risk: secondary outcomes of the SURMOUNT-OSA randomized trial. Image Credit: Mongkolchon Akesin / Shutterstock In a recent study published in the journal Nature Medicine, researchers reported results from the … Read more

Gut bacteria and genes jointly shape obesity risk, review reveals hidden links

A new scientific review uncovers how gut microbes passed from mother to child may hold the key to obesity’s genetic puzzle, offering fresh hope for more effective prevention strategies. Impact of the gut microbiota on BMI via hypothalamic control of appetite and metabolism, and mechanisms that underlie the transgenerational effects of the gut microbiota on … Read more

Hyderabad Doctor Reverses BP, Weight Loss with Sleep Fix

The Unexpected Link Between Sleep and Hypertension: A Path to Medication Freedom For many individuals managing high blood pressure, a daily regimen of medication feels unavoidable. However, a growing body of evidence suggests that addressing underlying sleep disorders can, in some cases, dramatically reduce – and even eliminate – the need for pharmaceutical intervention. A … Read more

Consider Salt Sensitivity in Women’s Midlife Hypertension

Americans eat too much salt, but the influence of dietary sodium is especially noticeable in women, whose blood pressure may become more salt sensitive in their 40s or 50s. Primary care providers should take note and not underestimate salt’s ability to affect blood pressure later in life, warn women’s health experts. Most adults have a … Read more

Rethinking Fibromyalgia: Nociplastic Pain’s Big Impact

The need to recognize and manage chronic nociplastic pain has become integral to rheumatology practice, as research over the past half-decade has affirmed that when central sensitization is present, patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), axial spondyloarthritis (AxSpA), and other rheumatologic diseases are less responsive — or nonresponsive — to peripherally and axially … Read more

Depressive, anxiety, and sleep disturbance symptoms in patients with obstructive sleep apnea: a network analysis perspective | BMC Psychiatry

Gottlieb DJ, Punjabi NM. Diagnosis and management of obstructive sleep apnea: a review. JAMA. 2020;323(14):1389–400. PubMed  Google Scholar  Steier JS, Bogan RK, Cano-Pumarega IM, Fleetham JA, Insalaco G, Lal C, Pépin JL, Randerath WJ, Redline S, Malhotra A. Recommendations for clinical management of excessive daytime sleepiness in obstructive sleep apnoea – A Delphi consensus study. … Read more

Surgery reduces accident risk in sleep apnea patients

Sleepiness at the wheel is a significant contributing factor to motor vehicle accidents. A new analysis published in Otolaryngology–Head and Neck Surgery reveals that for people with sleep apnea, getting surgery for their condition may lessen their risk of such accidents compared with using a Continuous Positive Airway Pressure (CPAP) device at night or receiving … Read more

Combined exposure to mixed brominated flame retardants on obstructive sleep apnea syndrome in US adults | BMC Public Health

De Wit CA, Alaee M, Muir DC. Levels and trends of brominated flame retardants in the Arctic. Chemosphere. 2006;64(2):209–33. Article  PubMed  Google Scholar  Wu H-D, Yang L-W, Deng D-Y, Jiang R-N, Song Z-K, Zhou L-T. The effects of brominated flame retardants (BFRs) on pro-atherosclerosis mechanisms. Ecotoxicol Environ Saf. 2023;262:115325. Article  CAS  PubMed  Google Scholar  Alaee … Read more