A recent study published in Engineering has shed light on a novel therapeutic target for improving anti-angiogenic treatment in colorectal cancer (CRC). The research, conducted by an international team of scientists from institutions including Sun Yat-sen University and The Chinese University of Hong Kong, identified the RNA N⁶-methyladenosine (m⁶A) reader insulin-like growth factor 2 mRNA-binding … Read more
Age is more than just one number. While neuroscientists used to think of cognitive aging as a single trendline, they now realize that vast individual differences require a more predictive and personalized approach. As they uncover more factors that affect cognition over time, they are realizing that modeling the aging brain requires more diverse data … Read more
Early detection and prompt treatment of acute pulmonary embolism (PE), a sudden and potentially life-threatening blood clot that blocks arteries in the lungs, is critical. Comprehensive recommendations for the evaluation, management and follow-up care for adults with acute PE are detailed in this new clinical practice guideline, published today in the American Heart Association’s flagship … Read more
Dr. Vadim Jucaud’s lab at the Terasaki Institute has developed a vascularized liver tissueoid-on-a-chip (LToC) platform that recapitulates key structural, functional, and immunological features of human liver tissue, enabling the study of liver regeneration and immune-mediated allograft rejection in a physiologically relevant human system. Liver transplantation remains the primary therapeutic option for patients with end-stage … Read more
New neuroimaging research shows that when sleep-deprived people lose focus, the brain briefly shifts toward sleep-like physiology, offering fresh insight into why cognitive performance declines without adequate rest. Study: Attentional failures after sleep deprivation are locked to joint neurovascular, pupil and cerebrospinal fluid flow dynamics. Image Credit: New Africa / Shuttertock In a recent study … Read more
Announcing a new article publication for Cardiovascular Innovations and Applications journal. Osteoprotegerin (OPG), a glycoprotein in the tumor necrosis factor superfamily, regulates bone metabolism by suppressing the formation and activation of osteoclasts. Nonetheless, increasing evidence underscores its physiological importance, particularly in cardiovascular diseases (CVDs). Elevated OPG levels are associated with atherosclerosis, arterial calcification, and heart … Read more
G-protein-coupled receptors (GPCRs) are one of the largest families of cell surface proteins in the human body that recognize hormones, neurotransmitters, and drugs. These receptors regulate a wide range of physiological processes and are the targets of more than 30% of currently marketed drugs. The histamine H1 receptor (H1R) is one such GPCR subtype that … Read more
Diabetic retinopathy develops through complex microvascular damage driven by chronic hyperglycemia, yet traditional risk factors such as disease duration or glycemic control explain only part of individual risk. The retina offers a unique, non-invasive view of microvascular health, where early functional abnormalities may appear before visible retinal lesions. Under normal conditions, retinal vessels automatically constrict … Read more
A molecule that helps regulate gene activity has also been shown to drive skin cancer growth and tumors’ ability to evade attack by the body’s immune system, a new study shows. Led by researchers at NYU Langone Health and its Perlmutter Cancer Center, the study showed that a key protein – the transcription factor HOXD13 … Read more
Atherosclerosis underlies most heart attacks and strokes and is now recognized as a chronic inflammatory disease rather than a simple disorder of cholesterol deposition. While immune cells such as macrophages have been widely studied, emerging evidence shows that vascular smooth muscle cells also play a central role in plaque development. These cells exhibit remarkable plasticity, … Read more