A new global initiative launched today aims to close a critical gap in ALS/MND drug discovery – current cell models used for testing treatments do not currently reflect the diverse nature of the disease – that affects both researchers developing therapies and the people urgently waiting for them. The ALS Therapy Development Institute (ALS TDI), … Read more
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) belong to a spectrum of neurodegenerative diseases with overlapping symptoms, characterized by muscle wasting, paralysis, dementia, and other serious impairments. There are currently no effective treatments. Many patients have a common hallmark: A protein called TDP-43 clumps together in the neurons of the brain to form tiny … Read more
Summary: Being an “early bird” and maintaining a physically active lifestyle may significantly reduce the risk of developing amyotrophic lateral sclerosis (ALS). A preliminary study involving over 500,000 participants found that those with a morning chronotype had a 20% lower risk of ALS compared to “night owls.” Additionally, participants who engaged in regular physical activity … Read more
Being an early bird, also called a morning person, and being more physically active are associated with lower risks of amyotrophic lateral sclerosis (ALS), according to a preliminary study released February 25, 2026, that will be presented at the American Academy of Neurology’s 78th Annual Meeting taking place April 18-22, 2026, in Chicago and online. … Read more
Eric Dane, best known for his role as Dr. Mark Sloan (“McSteamy”) on “Grey’s Anatomy” and as complicated father Cal Jacobs on “Euphoria,” died February 19, his family confirmed to People Magazine. Dane was diagnosed with amyotrophic lateral sclerosis, known as Lou Gehrig’s disease, in 2025. More from Variety “With heavy hearts, we share that Eric … Read more
Emerging evidence suggests widely used metabolic drugs could influence brain aging pathways, yet large clinical trials are still needed to confirm whether they truly alter the course of neurodegenerative disease. Study: The promise of GLP-1 receptor agonists for neurodegenerative diseases. Image Credit: Antonio Marca / Shutterstock In a recent review published in the Journal of Clinical … Read more
Even at relatively low pollution levels, chronic exposure to fine particles and nitrogen dioxide was linked to higher disease risk, faster functional decline, and greater need for invasive ventilation in people with motor neuron disease. Study: Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease. Image Credit: Kateryna Kon / Shutterstock … Read more
BREAKING: New Hope for Treating Mitochondrial Damage Table of Contents BREAKING: New Hope for Treating Mitochondrial Damage What We Know So Far targeting Mitochondrial Fission Uncovering a Vulnerable… The post Protect Mitochondria: Stress Damage Breakthrough appeared first on NewsyList. Source link
Summary: A groundbreaking experimental therapy for a rare, aggressive form of ALS caused by FUS gene mutations has produced surprising clinical improvements in some patients, including restored mobility and extended survival. The treatment uses antisense technology to silence the FUS gene, reducing toxic protein buildup in motor neurons. Two patients in a recent case series … Read more
Reduced levels of a critical protein are linked to devastating brain diseases like Alzheimer’s, frontotemporal dementia, and amyotrophic lateral sclerosis (ALS). Surprisingly, the protein shortage primarily affects the brain’s blood vessels. University of Connecticut researchers report in the April 16 issue of Science Advances that mutations in the TARDBP gene that reduce TDP-43 protein levels also impair the cells … Read more